United States securities and exchange commission logo January 6, 2022 Hamza Suria Chief Executive Officer ANAPTYSBIO, INC 10770 Wateridge Circle, Suite 210 San Diego, CA 92121 Re: ANAPTYSBIO, INC Registration Statement on Form S-3 Filed December 30, 2021 File No. 333-261953 Dear Hamza Suria: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Michael Davis at 202-551-4385 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Ryan Mitteness