United States securities and exchange commission logo

                          January 6, 2022

       Hamza Suria
       Chief Executive Officer
       10770 Wateridge Circle, Suite 210
       San Diego, CA 92121

                                                        Re: ANAPTYSBIO, INC
Statement on Form S-3
                                                            Filed December 30,
                                                            File No. 333-261953

       Dear Hamza Suria:

              This is to advise you that we have not reviewed and will not
review your registration

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Michael
Davis at 202-551-4385 with any questions.


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Ryan Mitteness