<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:03f094ff-9d23-4e7f-bf9b-c92f3b39058a,g:ec3e2754-9cfa-412b-95af-bd908cd3883c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CoverPage" xlink:type="simple" xlink:href="anab-20200619.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_821856de-532a-4be5-a11a-b5f21362322b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_DocumentType_821856de-532a-4be5-a11a-b5f21362322b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_c126fa0f-9fc8-45ac-bc12-e0bbc5a4fc11" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_DocumentPeriodEndDate_c126fa0f-9fc8-45ac-bc12-e0bbc5a4fc11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_6d6c9ada-93a4-4240-befa-a0f776df0d47" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityRegistrantName_6d6c9ada-93a4-4240-befa-a0f776df0d47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_4aa1cd43-86f7-4db0-ab7a-dd411a87f900" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityIncorporationStateCountryCode_4aa1cd43-86f7-4db0-ab7a-dd411a87f900" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_80de05fa-7f28-4af8-941d-b05dfab05123" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityFileNumber_80de05fa-7f28-4af8-941d-b05dfab05123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_0f3b1d9b-16b8-45e6-812f-3ca695a5f377" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityTaxIdentificationNumber_0f3b1d9b-16b8-45e6-812f-3ca695a5f377" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_bc44a294-d083-47d5-9f71-2edfd2f54976" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityAddressAddressLine1_bc44a294-d083-47d5-9f71-2edfd2f54976" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_3aa2c23f-62bc-4f59-b50e-912c36285580" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityAddressAddressLine2_3aa2c23f-62bc-4f59-b50e-912c36285580" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_1998fa05-d546-432c-b65d-de30dec94ae0" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityAddressCityOrTown_1998fa05-d546-432c-b65d-de30dec94ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_08d2b86c-b3af-483b-ac4a-a738b9409b38" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityAddressStateOrProvince_08d2b86c-b3af-483b-ac4a-a738b9409b38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_959122aa-690f-4e78-bf50-0688349d8c17" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityAddressPostalZipCode_959122aa-690f-4e78-bf50-0688349d8c17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_2470025f-95f0-4443-a713-3dbd9cbf9658" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_CityAreaCode_2470025f-95f0-4443-a713-3dbd9cbf9658" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_0afa6797-5e36-4a8c-87b7-6e967d00fea1" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_LocalPhoneNumber_0afa6797-5e36-4a8c-87b7-6e967d00fea1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_9e158ea1-3b9f-4f10-9fba-37282471e59e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_WrittenCommunications_9e158ea1-3b9f-4f10-9fba-37282471e59e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_61ee4a65-43b1-4ae1-8be3-0620ec0bd86e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_SolicitingMaterial_61ee4a65-43b1-4ae1-8be3-0620ec0bd86e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_2c25893c-9622-4164-8704-a08f98aff141" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_PreCommencementTenderOffer_2c25893c-9622-4164-8704-a08f98aff141" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_0c1d496a-e927-4ee2-bada-e9ae539c35a8" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_0c1d496a-e927-4ee2-bada-e9ae539c35a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_d5c1181f-8765-4c7d-9642-07cf76dafc4c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_Security12bTitle_d5c1181f-8765-4c7d-9642-07cf76dafc4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_834751d5-a739-4b47-bd92-d52f7ef16300" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_TradingSymbol_834751d5-a739-4b47-bd92-d52f7ef16300" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_8c3ab4f7-36ca-440a-806b-8b9a16c98245" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_SecurityExchangeName_8c3ab4f7-36ca-440a-806b-8b9a16c98245" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_0a43d926-2ae1-4d10-acf5-a875e23eda00" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityEmergingGrowthCompany_0a43d926-2ae1-4d10-acf5-a875e23eda00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_6945178a-1cd5-42ff-b22d-86e8e836c9aa" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_EntityCentralIndexKey_6945178a-1cd5-42ff-b22d-86e8e836c9aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_f62d203e-26f2-45b6-90cb-b60242cbf5ea" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_fc98f41d-613b-437d-a9fe-0a8e3f201ded" xlink:to="loc_dei_AmendmentFlag_f62d203e-26f2-45b6-90cb-b60242cbf5ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
