<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:60fd5aeb-5a6b-4dcb-8606-ebb2d97058fa,g:3846b1f4-dedc-4a00-b344-405f92d216c9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="anab-20231231.xsd#ConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_d86c7cfa-f2d5-46ef-98c2-e625b2804b81" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b61a9f05-b26d-4fcb-9518-b5ab78ab4efa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d86c7cfa-f2d5-46ef-98c2-e625b2804b81" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_b61a9f05-b26d-4fcb-9518-b5ab78ab4efa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_4404f49e-f690-4080-95ac-6b0f1353dea6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d86c7cfa-f2d5-46ef-98c2-e625b2804b81" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_4404f49e-f690-4080-95ac-6b0f1353dea6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_8d3c1589-6c2b-4b5c-9142-14eabd0aadd3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d86c7cfa-f2d5-46ef-98c2-e625b2804b81" xlink:to="loc_us-gaap_ReceivablesNetCurrent_8d3c1589-6c2b-4b5c-9142-14eabd0aadd3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_ced7db5b-2117-4bb2-adb4-0f35cc39b7f3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_d86c7cfa-f2d5-46ef-98c2-e625b2804b81" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_ced7db5b-2117-4bb2-adb4-0f35cc39b7f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_c1a8771c-5277-46e3-9bbd-53cb987393ea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_81f1388b-726f-4270-b5e1-eeec782f517e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c1a8771c-5277-46e3-9bbd-53cb987393ea" xlink:to="loc_us-gaap_LiabilitiesCurrent_81f1388b-726f-4270-b5e1-eeec782f517e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c9bd3fe1-4473-42d6-9dde-3cdd8ffb4faf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c1a8771c-5277-46e3-9bbd-53cb987393ea" xlink:to="loc_us-gaap_StockholdersEquity_c9bd3fe1-4473-42d6-9dde-3cdd8ffb4faf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_1e854a22-1714-4485-8c1b-f83000495c72" xlink:href="anab-20231231.xsd#anab_AdvanceFutureRoyaltiesLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c1a8771c-5277-46e3-9bbd-53cb987393ea" xlink:to="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_1e854a22-1714-4485-8c1b-f83000495c72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_9123224c-0968-4d76-9165-90990f3070f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_c1a8771c-5277-46e3-9bbd-53cb987393ea" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_9123224c-0968-4d76-9165-90990f3070f9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_4271a5f8-0104-483a-919f-db9e01179d1c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:to="loc_us-gaap_AssetsCurrent_4271a5f8-0104-483a-919f-db9e01179d1c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_0436a345-006f-43cb-a5e7-c3bf271da02e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_0436a345-006f-43cb-a5e7-c3bf271da02e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_d9b46c28-19e3-4d1d-84e9-2ede12d34759" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_d9b46c28-19e3-4d1d-84e9-2ede12d34759" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_2ce70c02-9be6-439c-92c5-3107dd7a3425" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_2ce70c02-9be6-439c-92c5-3107dd7a3425" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_6881607a-eea2-4e5c-bbff-0de3a34022b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8b83fe67-0f50-47b4-b911-e9dba862a95d" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_6881607a-eea2-4e5c-bbff-0de3a34022b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_8b0d8e3f-f36a-4790-ba5a-204684a3f59d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:to="loc_us-gaap_CommonStockValue_8b0d8e3f-f36a-4790-ba5a-204684a3f59d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_cb38cbfd-8730-4642-8d2d-3eda469b86e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:to="loc_us-gaap_AdditionalPaidInCapital_cb38cbfd-8730-4642-8d2d-3eda469b86e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e79b681b-366f-4032-8145-5e4341dd1e56" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_e79b681b-366f-4032-8145-5e4341dd1e56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3bcecbfa-c19c-43a3-aa73-4e819ff82223" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_3bcecbfa-c19c-43a3-aa73-4e819ff82223" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_7a440029-6e38-4ef3-82c3-ac8d6c4a357b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_2748c365-4438-440c-961e-3be58dc682d0" xlink:to="loc_us-gaap_PreferredStockValue_7a440029-6e38-4ef3-82c3-ac8d6c4a357b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_b85be2e1-e574-4114-b64b-af64fcbc9ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_f0ce5f03-36b2-4bb8-b5f2-6af564f390e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b85be2e1-e574-4114-b64b-af64fcbc9ae6" xlink:to="loc_us-gaap_AccountsPayableCurrent_f0ce5f03-36b2-4bb8-b5f2-6af564f390e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_32a4ce4f-1beb-4af7-9198-4450f1f67937" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b85be2e1-e574-4114-b64b-af64fcbc9ae6" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_32a4ce4f-1beb-4af7-9198-4450f1f67937" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_7804e09e-2907-47b2-ad76-cdfae8da3972" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_b85be2e1-e574-4114-b64b-af64fcbc9ae6" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_7804e09e-2907-47b2-ad76-cdfae8da3972" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="anab-20231231.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_69e570d8-ef75-4192-aaa8-24c04c5c65d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_42e5a259-3b30-4e8b-b31e-4d495e73bf6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_69e570d8-ef75-4192-aaa8-24c04c5c65d4" xlink:to="loc_us-gaap_NetIncomeLoss_42e5a259-3b30-4e8b-b31e-4d495e73bf6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_8a5b5362-e5db-400c-aaa6-58e550447873" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_69e570d8-ef75-4192-aaa8-24c04c5c65d4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodBeforeTax_8a5b5362-e5db-400c-aaa6-58e550447873" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_aa4ebc64-218c-4c8e-84c2-286162be49c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_32411eb1-99be-4ea5-a2ed-3dbaa6a1ca6d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_aa4ebc64-218c-4c8e-84c2-286162be49c5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_32411eb1-99be-4ea5-a2ed-3dbaa6a1ca6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_43e72bd6-0c51-4b41-811f-7ae4f55b27e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_aa4ebc64-218c-4c8e-84c2-286162be49c5" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_43e72bd6-0c51-4b41-811f-7ae4f55b27e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_e66348c7-c04e-4b80-a711-5149d2ba1bcb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_998b0e50-a3b2-46fa-bc52-d0b963950c40" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_e66348c7-c04e-4b80-a711-5149d2ba1bcb" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_998b0e50-a3b2-46fa-bc52-d0b963950c40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_b63dee25-04d1-4cc1-94e0-3910bb403ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_e66348c7-c04e-4b80-a711-5149d2ba1bcb" xlink:to="loc_us-gaap_InterestIncomeOther_b63dee25-04d1-4cc1-94e0-3910bb403ce6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesAndAmortizationOfAdvanceFutureRoyaltiesInterestExpense_4301e614-38cb-485e-b7b9-ee3a1d4ab518" xlink:href="anab-20231231.xsd#anab_NoncashAdvanceFutureRoyaltiesAndAmortizationOfAdvanceFutureRoyaltiesInterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_e66348c7-c04e-4b80-a711-5149d2ba1bcb" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesAndAmortizationOfAdvanceFutureRoyaltiesInterestExpense_4301e614-38cb-485e-b7b9-ee3a1d4ab518" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cc86b8c8-48ad-4f61-a4c5-23cb3fc83959" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_eecedbe3-c42a-4f41-ba10-db409585933b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cc86b8c8-48ad-4f61-a4c5-23cb3fc83959" xlink:to="loc_us-gaap_OperatingIncomeLoss_eecedbe3-c42a-4f41-ba10-db409585933b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d7b4bae8-c3dc-4d2a-84e2-22f0e50a725a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cc86b8c8-48ad-4f61-a4c5-23cb3fc83959" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_d7b4bae8-c3dc-4d2a-84e2-22f0e50a725a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_f6bfc727-b2d8-4bf4-8558-32da3a5f5407" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_f9ce3003-bd61-4e5c-9ce6-5cae3ed29198" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f6bfc727-b2d8-4bf4-8558-32da3a5f5407" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_f9ce3003-bd61-4e5c-9ce6-5cae3ed29198" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_c8dc79d5-671f-460b-80eb-bb5121f2ea94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f6bfc727-b2d8-4bf4-8558-32da3a5f5407" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_c8dc79d5-671f-460b-80eb-bb5121f2ea94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_7e5bf17e-bce8-4882-97a2-741bf24da71b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_f6bfc727-b2d8-4bf4-8558-32da3a5f5407" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_7e5bf17e-bce8-4882-97a2-741bf24da71b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_2a58056d-a4a1-48b4-9697-9f958ab240b9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_e61ddbca-1bd9-4cf3-92e4-0652a2acc55c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_2a58056d-a4a1-48b4-9697-9f958ab240b9" xlink:to="loc_us-gaap_OperatingExpenses_e61ddbca-1bd9-4cf3-92e4-0652a2acc55c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_bcee7bae-c67a-43ae-bbf8-031c3d77d426" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_2a58056d-a4a1-48b4-9697-9f958ab240b9" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_bcee7bae-c67a-43ae-bbf8-031c3d77d426" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="anab-20231231.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_d97c425f-3e37-49ab-bcac-47e0aab33a0e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_d97c425f-3e37-49ab-bcac-47e0aab33a0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_32aa57cd-cbc1-4980-9d0e-04682474671f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_NetIncomeLoss_32aa57cd-cbc1-4980-9d0e-04682474671f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_a8279d75-873c-47bd-a53d-a64823551876" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_a8279d75-873c-47bd-a53d-a64823551876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_9f24bf67-dbd2-4c96-97b4-af1497b8dd72" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_9f24bf67-dbd2-4c96-97b4-af1497b8dd72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_1fc1ace5-04df-40d3-ad18-8bd158b582f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_1fc1ace5-04df-40d3-ad18-8bd158b582f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_d8f8bf20-48f9-492b-8f44-378d84000d4b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_ShareBasedCompensation_d8f8bf20-48f9-492b-8f44-378d84000d4b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_7d179cf8-7a08-4432-8090-8fd558dd1c37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_7d179cf8-7a08-4432-8090-8fd558dd1c37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c7a78a24-d544-493d-a2ed-660a8a46f211" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c7a78a24-d544-493d-a2ed-660a8a46f211" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ea8c665b-8358-4f39-84ab-07eef31316ea" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ea8c665b-8358-4f39-84ab-07eef31316ea" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_92bbe3ca-4c46-4a02-b3ec-86333e674300" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_92bbe3ca-4c46-4a02-b3ec-86333e674300" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_98e996b6-c7c8-48fc-9fa0-9061a355af16" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_48c59b9f-10ba-4437-bcb7-e26d284e40a4" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_98e996b6-c7c8-48fc-9fa0-9061a355af16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_fb2d536a-86df-42f3-b4e5-ec7cac18573b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9d733e56-b3a5-4671-ad72-ed09c5c3dc09" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_fb2d536a-86df-42f3-b4e5-ec7cac18573b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9d733e56-b3a5-4671-ad72-ed09c5c3dc09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a7f36fd2-089b-4fb8-b6fe-47a822ae77e8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_fb2d536a-86df-42f3-b4e5-ec7cac18573b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a7f36fd2-089b-4fb8-b6fe-47a822ae77e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_66f2e57a-09af-43f3-a28d-720f9c348b18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_fb2d536a-86df-42f3-b4e5-ec7cac18573b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_66f2e57a-09af-43f3-a28d-720f9c348b18" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4b7d770c-f278-485f-a353-6540c8525048" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_980be27f-be7c-42fc-9a04-e5f34c1a7e58" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4b7d770c-f278-485f-a353-6540c8525048" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_980be27f-be7c-42fc-9a04-e5f34c1a7e58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_6364d11c-7f3e-4abb-bf33-59bfb7d6a84c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4b7d770c-f278-485f-a353-6540c8525048" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_6364d11c-7f3e-4abb-bf33-59bfb7d6a84c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_f89feed5-2fc4-4e4d-98d3-197e89539c16" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4b7d770c-f278-485f-a353-6540c8525048" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_f89feed5-2fc4-4e4d-98d3-197e89539c16" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_edff26f7-95bf-4975-9316-811eb9c4fb0f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_4b7d770c-f278-485f-a353-6540c8525048" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_edff26f7-95bf-4975-9316-811eb9c4fb0f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_PaymentsOfAdvanceFutureRoyaltiesIssuanceCosts_da43802a-48f9-4479-8271-f0c59fd8cf5e" xlink:href="anab-20231231.xsd#anab_PaymentsOfAdvanceFutureRoyaltiesIssuanceCosts"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:to="loc_anab_PaymentsOfAdvanceFutureRoyaltiesIssuanceCosts_da43802a-48f9-4479-8271-f0c59fd8cf5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9e0bbe31-b447-42a9-aa8d-892329041990" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_9e0bbe31-b447-42a9-aa8d-892329041990" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ProceedsFromSaleOfAdvanceFutureRoyalties_00fbf946-724d-46bc-beea-a032e19f3371" xlink:href="anab-20231231.xsd#anab_ProceedsFromSaleOfAdvanceFutureRoyalties"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:to="loc_anab_ProceedsFromSaleOfAdvanceFutureRoyalties_00fbf946-724d-46bc-beea-a032e19f3371" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_6f9f0d12-9253-445f-abdb-7edbccfe87a4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_6f9f0d12-9253-445f-abdb-7edbccfe87a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RepaymentOfAdvanceFutureRoyaltyAndMilestones_fa9f01d1-e99c-4b05-8788-a54e6b26b44b" xlink:href="anab-20231231.xsd#anab_RepaymentOfAdvanceFutureRoyaltyAndMilestones"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_24de40d4-a960-4870-8e23-a9534f913947" xlink:to="loc_anab_RepaymentOfAdvanceFutureRoyaltyAndMilestones_fa9f01d1-e99c-4b05-8788-a54e6b26b44b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_be95104b-eaaf-498c-a279-7e07542cf645" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_af53e9d9-adca-422e-8df9-cc79430c7953" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_be95104b-eaaf-498c-a279-7e07542cf645" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_af53e9d9-adca-422e-8df9-cc79430c7953" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_c1529897-e1fe-4835-994c-88313d837520" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_be95104b-eaaf-498c-a279-7e07542cf645" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_c1529897-e1fe-4835-994c-88313d837520" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_8710cf21-ef4e-485d-8022-f7a198f5fdb4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_8710cf21-ef4e-485d-8022-f7a198f5fdb4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_d8d04f8f-64ad-4a6c-a660-1325a41308bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_d8d04f8f-64ad-4a6c-a660-1325a41308bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AccruedResearchAndDevelopmentExpensesCurrent_063ebb97-8866-4d92-be8e-865cd68130c2" xlink:href="anab-20231231.xsd#anab_AccruedResearchAndDevelopmentExpensesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:to="loc_anab_AccruedResearchAndDevelopmentExpensesCurrent_063ebb97-8866-4d92-be8e-865cd68130c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AccruedCommonStockRepurchased_657270df-1f08-4fd7-9482-3fb38f8609c5" xlink:href="anab-20231231.xsd#anab_AccruedCommonStockRepurchased"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:to="loc_anab_AccruedCommonStockRepurchased_657270df-1f08-4fd7-9482-3fb38f8609c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e763d2aa-aef1-424d-8901-2d0ff1810a55" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_01e73e01-bdeb-477d-a917-a7ec60e98dd4" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_e763d2aa-aef1-424d-8901-2d0ff1810a55" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5a8c626-530b-4293-8f92-6c78c5638120" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4f5c4b27-7c8f-4f25-a2fa-fbe7b249f657" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5a8c626-530b-4293-8f92-6c78c5638120" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_4f5c4b27-7c8f-4f25-a2fa-fbe7b249f657" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_465827dd-42a0-406c-97c2-ee891c368d8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5a8c626-530b-4293-8f92-6c78c5638120" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_465827dd-42a0-406c-97c2-ee891c368d8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_dc069f60-42ff-49a1-b212-76773fc6ef76" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_f5a8c626-530b-4293-8f92-6c78c5638120" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_dc069f60-42ff-49a1-b212-76773fc6ef76" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4a6903df-0a74-4c9f-aeda-7d468e58ab59" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_1a7a2136-e95d-4ce2-82be-9421b603a994" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4a6903df-0a74-4c9f-aeda-7d468e58ab59" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_1a7a2136-e95d-4ce2-82be-9421b603a994" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_02df9fa8-21d9-4fb1-8956-bdccfc07cdda" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_4a6903df-0a74-4c9f-aeda-7d468e58ab59" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_02df9fa8-21d9-4fb1-8956-bdccfc07cdda" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_442018f8-62a2-4ffa-acc6-2f76f2ca7885" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_f75a3d8d-2456-4127-839b-d72eec7066f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_442018f8-62a2-4ffa-acc6-2f76f2ca7885" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_f75a3d8d-2456-4127-839b-d72eec7066f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_03566382-cb21-4924-95db-a24e76f62799" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_442018f8-62a2-4ffa-acc6-2f76f2ca7885" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_03566382-cb21-4924-95db-a24e76f62799" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_20fcc9f8-ffe3-4d06-a326-7fc2a1266fb5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_20fcc9f8-ffe3-4d06-a326-7fc2a1266fb5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_06823377-e2c3-4512-9bc7-b0f9d4db1a84" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_06823377-e2c3-4512-9bc7-b0f9d4db1a84" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_4b5acb4b-dd2a-421d-a8df-386ede97467e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_4b5acb4b-dd2a-421d-a8df-386ede97467e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_a848dfe2-554b-4bdc-a564-ba231068de66" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_a848dfe2-554b-4bdc-a564-ba231068de66" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_1410c0be-92fe-4c9c-9692-627bdb9a1555" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_1410c0be-92fe-4c9c-9692-627bdb9a1555" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_217881eb-082e-4333-9748-06b16670cddc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_ac9476c2-5279-4648-9763-4e9308be91b3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_217881eb-082e-4333-9748-06b16670cddc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails_1" xlink:type="simple" xlink:href="anab-20231231.xsd#CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails_1"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsunderOperatingLeasesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_7ec81f6e-5e17-44e6-9628-e780eb1a1534" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_21e94754-9305-49b9-8c82-41c1955f63c1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_7ec81f6e-5e17-44e6-9628-e780eb1a1534" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_21e94754-9305-49b9-8c82-41c1955f63c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_f22b495d-3d96-48db-9096-ef11771c0596" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_7ec81f6e-5e17-44e6-9628-e780eb1a1534" xlink:to="loc_us-gaap_OperatingLeaseLiability_f22b495d-3d96-48db-9096-ef11771c0596" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/IncomeTaxesScheduleofLossbeforeIncomeTaxProvisionDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#IncomeTaxesScheduleofLossbeforeIncomeTaxProvisionDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/IncomeTaxesScheduleofLossbeforeIncomeTaxProvisionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a1880163-3cfc-49be-bb46-26e04ede9859" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_c60d3bf8-0444-43fb-bbeb-8a30ed7a2a94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a1880163-3cfc-49be-bb46-26e04ede9859" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_c60d3bf8-0444-43fb-bbeb-8a30ed7a2a94" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_bc17d826-d7f8-4bee-b79e-7e05f2aeed0b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_a1880163-3cfc-49be-bb46-26e04ede9859" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_bc17d826-d7f8-4bee-b79e-7e05f2aeed0b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/IncomeTaxesDeferredtaxassetsandliabilitiesDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#IncomeTaxesDeferredtaxassetsandliabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/IncomeTaxesDeferredtaxassetsandliabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_anab_DeferredTaxAssetsNetBeforeValuationAllowance_17b4746e-4044-4b40-85f5-6fcb6060178f" xlink:href="anab-20231231.xsd#anab_DeferredTaxAssetsNetBeforeValuationAllowance"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_eb44184c-9b97-4cf5-8070-edd542918a44" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_anab_DeferredTaxAssetsNetBeforeValuationAllowance_17b4746e-4044-4b40-85f5-6fcb6060178f" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_eb44184c-9b97-4cf5-8070-edd542918a44" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_2a93ceea-a246-49b9-9bdf-f10f86e7808c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_anab_DeferredTaxAssetsNetBeforeValuationAllowance_17b4746e-4044-4b40-85f5-6fcb6060178f" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_2a93ceea-a246-49b9-9bdf-f10f86e7808c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_eccf7541-18ca-494f-8e73-787c5eaaa2b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_8e990bb1-5ef4-43d1-8c92-a722fc3102ec" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesLeasingArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_eccf7541-18ca-494f-8e73-787c5eaaa2b3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesLeasingArrangements_8e990bb1-5ef4-43d1-8c92-a722fc3102ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_d8c3492e-ae5a-497e-bf03-c50d2295c8b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesOther"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_eccf7541-18ca-494f-8e73-787c5eaaa2b3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_d8c3492e-ae5a-497e-bf03-c50d2295c8b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_0557812e-799b-4416-b937-3c4bc09eabfd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_eccf7541-18ca-494f-8e73-787c5eaaa2b3" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_0557812e-799b-4416-b937-3c4bc09eabfd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_97f49f82-144b-49a3-acfd-3d130ddd4537" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_DeferredTaxAssetsNetBeforeValuationAllowance_1147089f-cd43-4e3f-a671-5b3c74944cb1" xlink:href="anab-20231231.xsd#anab_DeferredTaxAssetsNetBeforeValuationAllowance"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_97f49f82-144b-49a3-acfd-3d130ddd4537" xlink:to="loc_anab_DeferredTaxAssetsNetBeforeValuationAllowance_1147089f-cd43-4e3f-a671-5b3c74944cb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_ea5f8901-1dd1-42e4-8e98-62fd85ae1ec8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_97f49f82-144b-49a3-acfd-3d130ddd4537" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_ea5f8901-1dd1-42e4-8e98-62fd85ae1ec8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_DeferredTaxAssetsLeaseLiability_f61d4969-db21-4e42-86a7-08baf3dbc5b8" xlink:href="anab-20231231.xsd#anab_DeferredTaxAssetsLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_anab_DeferredTaxAssetsLeaseLiability_f61d4969-db21-4e42-86a7-08baf3dbc5b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2be118d7-d6c1-4695-be48-2299046189f2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch_2be118d7-d6c1-4695-be48-2299046189f2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_00f5b167-4325-4a46-b9fa-5c1a3d04cf25" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_00f5b167-4325-4a46-b9fa-5c1a3d04cf25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_54973407-1a8f-41bf-8245-82770d0e7326" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_54973407-1a8f-41bf-8245-82770d0e7326" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_cceb9dc3-ae1e-447a-a0c1-8883e70f397c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_cceb9dc3-ae1e-447a-a0c1-8883e70f397c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_DeferredTaxAssetsResearchAndDevelopment_5e623cf1-20dd-4bd3-8ae6-4b5ddd8a9dac" xlink:href="anab-20231231.xsd#anab_DeferredTaxAssetsResearchAndDevelopment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_anab_DeferredTaxAssetsResearchAndDevelopment_5e623cf1-20dd-4bd3-8ae6-4b5ddd8a9dac" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_3a156048-c3c0-41b4-a16f-10bb64079796" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_4fdb557b-ec1f-4059-8dd4-22bb84ef4549" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_3a156048-c3c0-41b4-a16f-10bb64079796" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/IncomeTaxesReconciliationofincometaxesDetails" xlink:type="simple" xlink:href="anab-20231231.xsd#IncomeTaxesReconciliationofincometaxesDetails"/>
  <link:calculationLink xlink:role="http://www.anaptysbio.com/role/IncomeTaxesReconciliationofincometaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_8073a3b8-2230-4247-857d-015cc3d7eb37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_8073a3b8-2230-4247-857d-015cc3d7eb37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_eae2ddf3-1e03-468b-96ae-f151ec05930d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationTaxExemptIncome"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxExemptIncome_eae2ddf3-1e03-468b-96ae-f151ec05930d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_3b666d33-5d9d-405c-8aba-f922138351b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_3b666d33-5d9d-405c-8aba-f922138351b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_EffectiveIncomeTaxRateReconciliationNondeductableCompensationAmount_8b8e4f37-d555-4f48-b310-028df7dacb65" xlink:href="anab-20231231.xsd#anab_EffectiveIncomeTaxRateReconciliationNondeductableCompensationAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_anab_EffectiveIncomeTaxRateReconciliationNondeductableCompensationAmount_8b8e4f37-d555-4f48-b310-028df7dacb65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_1691b609-5af4-4cd7-9843-caccf3a4668a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_1691b609-5af4-4cd7-9843-caccf3a4668a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_12d34dcd-1be3-45b5-911e-23154eabb639" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_12d34dcd-1be3-45b5-911e-23154eabb639" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_2c40406f-2f6a-428a-b7eb-a583b981f03a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_2c40406f-2f6a-428a-b7eb-a583b981f03a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_92cfd92a-0316-4949-8e6d-a5094adfac11" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_9506622b-5427-411b-ba44-0e24cf4dddf1" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_92cfd92a-0316-4949-8e6d-a5094adfac11" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
