Statement of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities [Abstract] Net loss Net Income (Loss) Attributable to Parent Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Depreciation and amortization Depreciation, Depletion and Amortization Stock-based compensation Share-based Compensation And Issuance Of Stock And Warrants For Services Or Claims Share-based Compensation And Issuance Of Stock And Warrants For Services Or Claims Change in fair value of liability for preferred stock warrants Fair Value Adjustment of Warrants (Income) loss from investments Unrealized Gain (Loss) on Investments Non-cash interest expense Other Noncash Income (Expense) Loss on disposal of property and equipment Gain (Loss) on Disposition of Property Plant Equipment Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Receivable from collaborative partners Increase (Decrease) in Contract with Customer, Asset Australian tax incentive receivable Increase (Decrease) in Income Taxes Receivable Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Accounts payable and other liabilities Increase (Decrease) in Accounts Payable and Accrued Liabilities Income taxes Increase (Decrease) in Income Taxes Payable Deferred revenue Increase (Decrease) in Contract with Customer, Liability Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities [Abstract] Acquisition of investments Payments to Acquire Debt Securities, Available-for-sale Sales and maturities of investments Proceeds from Sale and Maturity of Debt Securities, Available-for-sale Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from public offerings, net of underwriters' fees Proceeds from Issuance of Common Stock Proceeds from issuance of common stock, upon the exercise of stock options Proceeds from Stock Options Exercised Proceeds from issuance of common stock, upon the exercise of warrants Proceeds from Warrant Exercises Payments on notes payable Repayments of Notes Payable Proceeds from debt Proceeds from (Repayments of) Debt Payments for repurchase of common stock Payments for Repurchase of Common Stock Payments of Stock Issuance Costs Payments of Stock Issuance Costs Payments for debt issuance costs Payments of Debt Issuance Costs Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Net increase (decrease) in cash, cash equivalents, and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect Cash, cash equivalents and restricted cash, beginning of period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents and restricted cash, end of period SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION Supplemental Cash Flow Information [Abstract] Interest paid Interest Paid, Excluding Capitalized Interest, Operating Activities Non-cash investing and financing activities: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Fair value of warrants issued with debt Fair Value Of Warrants Issued With Debt Fair Value Of Warrants Issued With Debt Amounts accrued for property and equipment Capital Expenditures Incurred but Not yet Paid Amounts accrued for offering costs Stock Issuance Costs Incurred During Noncash Transaction Stock Issuance Costs Incurred During Noncash Transaction Reclassification of warrants to equity Transfer Of Warrants To Equity Transfer Of Warrants To Equity Disclosure of Compensation Related Costs, Share-based Payments [Abstract] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] 2017 Equity Incentive Plan Equity Incentive Plan, 2017 [Member] Equity Incentive Plan, 2017 [Member] 2017 Employee Stock Purchase Plan Employee Stock Purchase Plan, 2017 [Member] Employee Stock Purchase Plan, 2017 [Member] Award Type [Axis] Award Type [Axis] Equity Award [Domain] Equity Award [Domain] Employee Stock Employee Stock [Member] Employee and Nonemployee Stock Options Employee And Nonemployee Stock Options [Member] Employee And Nonemployee Stock Options [Member] Options Employee Stock Option [Member] Title of Individual [Axis] Title of Individual [Axis] Relationship to Entity [Domain] Relationship to Entity [Domain] Director Director [Member] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Annual increase in number of shares available for issuance Common Stock, Capital Shares Reserved For Future Issuance, Annual Increase, Percent Of Aggregate Shares Outstanding Common Stock, Capital Shares Reserved For Future Issuance, Annual Increase, Percent Of Aggregate Shares Outstanding Capital shares reserved for future issuance, increase (in shares) Common Stock, Capital Shares Reserved For Future Issuance, Increase Common Stock, Capital Shares Reserved For Future Issuance, Increase Award vesting period (in years) Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Award expiration period (in years) Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Unrecognized compensation cost Employee And Nonemployee Service Share-based Compensation, Nonvested Awards, Compensation Not Yet Recognized, Stock Options Employee And Nonemployee Service Share-based Compensation, Nonvested Awards, Compensation Not Yet Recognized, Stock Options Weighted average period remaining for amortization of unrecognized compensation cost (in years) Employee And Nonemployee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not Yet Recognized, Period For Recognition Employee And Nonemployee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not Yet Recognized, Period For Recognition Accounting Policies [Abstract] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Convertible preferred stock Convertible Preferred Stock [Member] Warrants Warrant [Member] Class of Stock [Axis] Class of Stock [Axis] Class of Stock [Domain] Class of Stock [Domain] Preferred Stock Preferred Stock [Member] Common Stock Common Stock [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Dilutive securities excluded from computation of net loss per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Statement of Financial Position [Abstract] ASSETS Assets [Abstract] Current assets: Assets, Current [Abstract] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Australian tax incentive receivable Research And Development Tax Incentive Credit Receivable, Current Research And Development Tax Incentive Credit Receivable, Current Short-term investments Debt Securities, Available-for-sale, Current Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Total current assets Assets, Current Property and equipment, net Property, Plant and Equipment, Net Long-term investments Debt Securities, Available-for-sale, Noncurrent Other long-term assets Other Assets, Noncurrent Restricted cash Restricted Cash and Cash Equivalents, Noncurrent Total assets Assets LIABILITIES, PREFERRED STOCK AND STOCKHOLDERS’ EQUITY Liabilities and Equity [Abstract] Current liabilities: Liabilities, Current [Abstract] Accounts payable Accounts Payable, Current Accrued expenses Accrued Liabilities, Current Notes payable, current portion Notes Payable, Current Other current liabilities Other Liabilities, Current Total current liabilities Liabilities, Current Notes payable, net of current portion Notes Payable to Bank, Noncurrent Deferred rent Accrued Rent, Noncurrent Stockholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Preferred stock, $0.001 par value, 10,000 shares authorized and no shares, issued or outstanding at December 31, 2018 and December 31, 2017, respectively Preferred Stock, Value, Issued Common stock, $0.001 par value, 500,000 shares authorized, 26,922 shares and 23,791 shares issued and outstanding at December 31, 2018 and December 31, 2017, respectively Common Stock, Value, Issued Additional paid in capital Additional Paid in Capital Accumulated other comprehensive loss Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated deficit Retained Earnings (Accumulated Deficit) Total stockholders’ equity Stockholders' Equity Attributable to Parent Total liabilities, preferred stock and stockholders’ equity Liabilities and Equity Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Class of Warrant or Right [Table] Class of Warrant or Right [Table] Sale of Stock [Axis] Sale of Stock [Axis] Sale of Stock [Domain] Sale of Stock [Domain] IPO IPO [Member] Underwriters' option Over-Allotment Option [Member] Equity Components [Axis] Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Class of Warrant or Right [Line Items] Class of Warrant or Right [Line Items] Common shares issued (in shares) Stock Issued During Period, Shares, New Issues Share price (in dollars per share) Shares Issued, Price Per Share Proceeds from public offerings, net of underwriters' fees Proceeds from Issuance Initial Public Offering Convertible preferred stock, converted to common stock (in shares) Stock Issued During Period, Shares, Conversion of Convertible Securities Number of shares called by warrants (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights Reverse stock split, conversion ratio Stockholders' Equity Note, Stock Split, Conversion Ratio Proceeds, net of underwriters' fees Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Schedule of future minimum annual obligations under operating leases Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block] Quarterly Financial Information Disclosure [Abstract] Operating income (loss) Operating Income (Loss) Net income (loss) Net Income (Loss) Available to Common Stockholders, Basic Per common share: Earnings Per Share, Basic and Diluted [Abstract] Loss per share, basic (in dollars per share) Earnings Per Share, Basic Loss per share, diluted (in dollars per share) Earnings Per Share, Diluted Risk-free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Expected volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Expected dividend yield Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate Expected term (in years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Weighted average grant date fair value per share (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Income Tax Disclosure [Abstract] Deferred Tax Assets: Deferred Tax Assets, Gross [Abstract] Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards Research and development credits Deferred Tax Assets, Tax Credit Carryforwards, Research Other, net Deferred Tax Assets, Other Total deferred tax assets Deferred Tax Assets, Gross Deferred Tax Liabilities: Components of Deferred Tax Liabilities [Abstract] Fixed assets Deferred Tax Liabilities, Property, Plant and Equipment Total deferred tax liabilities Deferred Tax Liabilities, Gross Net deferred tax assets Deferred Tax Assets, Net, Before Valuation Allowance Deferred Tax Assets, Net, Before Valuation Allowance Less: valuation allowance Deferred Tax Assets, Valuation Allowance Deferred tax assets, net of valuation allowance Deferred Tax Assets, Net Schedule of Operating Leased Assets [Table] Schedule of Operating Leased Assets [Table] Lease Arrangement, Type [Axis] Lease Arrangement, Type [Axis] Lease Arrangement, Type [Domain] Lease Arrangement, Type [Domain] New sub-lease agreement New Sub-lease Agreement [Member] New Sub-lease Agreement [Member] Original lease agreement Original Lease Agreement [Member] Original Lease Agreement [Member] Operating Leased Assets [Line Items] Operating Leased Assets [Line Items] Operating lease, term of contract Lessee, Operating Lease, Term of Contract Operating lease, rented square feet (in square feet) Area of Real Estate Property Number of one year renewal options Lessee, Operating Lease, One Year Renewal Options, Number Lessee, Operating Lease, One Year Renewal Options, Number Operating lease, renewal term Lessee, Operating Lease, Renewal Term Operating leases, rent expense Operating Leases, Rent Expense, Net Deferred rent expense Deferred Rent Credit, Noncurrent Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] Operating Leases, Future Minimum Payments Due, Fiscal Year Maturity [Abstract] 2019 Operating Leases, Future Minimum Payments Due, Next Twelve Months 2020 Operating Leases, Future Minimum Payments, Due in Two Years 2021 Operating Leases, Future Minimum Payments, Due in Three Years 2022 Operating Leases, Future Minimum Payments, Due in Four Years 2023 Operating Leases, Future Minimum Payments, Due in Five Years Thereafter Operating Leases, Future Minimum Payments, Due Thereafter Total minimum payments required Operating Leases, Future Minimum Payments Due Summary of Activity Related to Stock Option Awards Share-based Compensation, Stock Options, Activity [Table Text Block] Summary of Weighted Average Assumptions in Stock Option Valuations Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Summary of Non-cash Stock-based Compensation Expense Schedule of Compensation Cost for Share-based Payment Arrangements, Allocation of Share-based Compensation Costs by Plan [Table Text Block] Number of reportable segments Number of Reportable Segments Restricted Cash Restricted Cash Number of banks utilized for diversification of funds (in banks) Number Of Financial Institutions Utilized For Diversification Of Funds Number Of Financial Institutions Utilized For Diversification Of Funds New Accounting Pronouncements or Change in Accounting Principle [Table] New Accounting Pronouncements or Change in Accounting Principle [Table] Range [Axis] Range [Axis] Range [Domain] Range [Domain] Minimum Minimum [Member] Maximum Maximum [Member] Scenario [Axis] Scenario [Axis] Scenario, Unspecified [Domain] Scenario, Unspecified [Domain] Forecast Scenario, Forecast [Member] Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] Type of Adoption [Domain] ASU 2016-02 Accounting Standards Update 2016-02 [Member] New Accounting Pronouncements or Change in Accounting Principle [Line Items] New Accounting Pronouncements or Change in Accounting Principle [Line Items] Property and equipment, useful life Property, Plant and Equipment, Useful Life Long-lived asset impairment charges Tangible Asset Impairment Charges Australian research and development tax incentive, threshold for reimbursable period Income Tax Incentive, Research And Development, Revenue Threshold For Reimbursable Period Income Tax Incentive, Research And Development, Revenue Threshold For Reimbursable Period ROU asset Operating Lease, Right-of-Use Asset Lease liability Operating Lease, Liability Fair Value Disclosures [Abstract] Fair Value, by Balance Sheet Grouping [Table] Fair Value, by Balance Sheet Grouping [Table] Measurement Basis [Axis] Measurement Basis [Axis] Fair Value Measurement [Domain] Fair Value Measurement [Domain] Portion at Fair Value Measurement Portion at Fair Value Measurement [Member] Carrying Amount Reported Value Measurement [Member] Fair Value Estimate of Fair Value Measurement [Member] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Notes payable Notes Payable, Fair Value Disclosure Debt Disclosure [Abstract] Notes Payable Debt Disclosure [Text Block] Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Income Tax Authority [Axis] Income Tax Authority [Axis] Income Tax Authority [Domain] Income Tax Authority [Domain] Federal tax authority Domestic Tax Authority [Member] State tax authority State and Local Jurisdiction [Member] Foreign Tax Authority Foreign Tax Authority [Member] Tax Period [Axis] Tax Period [Axis] Tax Period [Domain] Tax Period [Domain] 2018 Tax Year 2018 [Member] Tax Credit Carryforward [Axis] Tax Credit Carryforward [Axis] Tax Credit Carryforward, Name [Domain] Tax Credit Carryforward, Name [Domain] Research Tax Credit Carryforward Research Tax Credit Carryforward [Member] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Net operating loss carryforwards Operating Loss Carryforwards Research tax credit carryforwards Tax Credit Carryforward, Amount Net operating loss carryforward, utilization limitation Operating Loss Carryforwards, Limitations On Use, Amount Operating Loss Carryforwards, Limitations On Use, Amount Tax credit carryforward, utilization limitation Tax Credit Carryforward, Limitations On Use, Amount Tax Credit Carryforward, Limitations On Use, Amount Excess tax benefits associated with the exercise of non-qualified stock options Effective Income Tax Rate Reconciliation, Share-based Compensation, Excess Tax Benefit, Amount Disqualifying dispositions of incentive stock options Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Disqualifying Dispositions Of Incentive Stock Options Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Disqualifying Dispositions Of Incentive Stock Options Tax act, change in tax rate, decrease in deferred tax asset Tax Cuts And Jobs Act Of 2017, Change In Tax Rate, Deferred Tax Asset, Income Tax Expense Amount of income tax expense for remeasurement of deferred tax asset from change in tax rate pursuant to Tax Cuts and Jobs Act of 2017. Unrecognized tax benefits that if recognized and realized would affect the effective tax rate Unrecognized Tax Benefits that Would Impact Effective Tax Rate Interest or penalties on uncertain tax benefits Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Notes Payable to Banks Notes Payable to Banks [Member] Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Loan and Security Agreement (LSA) Loan And Security Agreement [Member] Loan And Security Agreement [Member] Term Loans Term Loans [Member] Term Loans [Member] Term A Loans Term A Loans [Member] Term A Loans [Member] Term B and Term C Loans Term B Loans And Term C Loans [Member] Term B Loans And Term C Loans [Member] Class of Warrant or Right [Axis] Class of Warrant or Right [Axis] Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Term A Loan Warrants Term A Loan Warrants [Member] Term A Loan Warrants [Member] Term B And C Loans Warrants Term B And C Loans Warrants [Member] Term B And C Loans Warrants [Member] Series C Preferred Stock Series C Preferred Stock [Member] Derivative Instrument [Axis] Derivative Instrument [Axis] Derivative Contract [Domain] Derivative Contract [Domain] Measurement Input Type [Axis] Measurement Input Type [Axis] Measurement Input Type [Domain] Measurement Input Type [Domain] Price volatility percent Measurement Input, Price Volatility [Member] Contractual term Measurement Input, Expected Term [Member] Risk-free interest rate Measurement Input, Risk Free Interest Rate [Member] Variable Rate [Axis] Variable Rate [Axis] Variable Rate [Domain] Variable Rate [Domain] 3-Month LIBOR London Interbank Offered Rate (LIBOR) [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Debt instrument, maximum borrowing capacity Debt Instrument, Maximum Borrowing Capacity Debt Instrument, Maximum Borrowing Capacity Number of loan installments (in installments) Debt Instrument, Number Of Loan Installments Debt Instrument, Number Of Loan Installments Aggregate borrowing capacity Debt Instrument, Face Amount Aggregate draw on term loan Proceeds from Notes Payable Fixed interest rate Debt Instrument, Interest Rate, Stated Percentage Warrant exercise price (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights U.S. treasury securities Derivative Liability Measurement Input (as a percent) Debt Instrument, Measurement Input Contractual term (in years) Warrants and Rights Outstanding, Term Number of principal and interest payments (in payments) Debt Instrument, Periodic Payment, Number Of Principal And Interest Payments Debt Instrument, Periodic Payment, Number Of Principal And Interest Payments Basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Interest rate at period end Debt Instrument, Interest Rate At End Of Period Debt Instrument, Interest Rate At End Of Period Final payment fee Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid Notes payable Notes Payable Debt instrument discounts Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Effective interest rate Debt Instrument, Interest Rate, Effective Percentage Long-term Debt, Fiscal Year Maturity [Abstract] Long-term Debt, Fiscal Year Maturity [Abstract] 2019 Long-term Debt, Maturities, Repayments of Principal in Next Twelve Months 2020 Long-term Debt, Maturities, Repayments of Principal in Year Two Balance Sheet Related Disclosures [Abstract] Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Laboratory equipment Laboratory Equipment [Member] Laboratory Equipment [Member] Office furniture and equipment Office Equipment [Member] Leasehold improvements Leasehold Improvements [Member] Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Property and equipment, gross Property, Plant and Equipment, Gross Less: accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Total property and equipment, net Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Measurement Frequency [Axis] Measurement Frequency [Axis] Fair Value, Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value, Measurements, Recurring Fair Value, Measurements, Recurring [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Quoted Market Prices for Identical Assets (Level 1) Fair Value, Inputs, Level 1 [Member] Significant Other Observable Inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Significant Unobservable Inputs (Level 3) Fair Value, Inputs, Level 3 [Member] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Money market funds Money Market Funds [Member] Mutual funds Mutual Fund [Member] Financial Instrument [Axis] Financial Instrument [Axis] Financial Instruments [Domain] Financial Instruments [Domain] U.S. treasury securities US Treasury Securities [Member] Certificates of deposit Certificates of Deposit [Member] Agency securities US Government Agencies Debt Securities [Member] Commercial and corporate obligations Commercial And Corporate Obligations [Member] Commercial And Corporate Obligations [Member] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Investments at fair value Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Total Fair Value Debt Securities, Available-for-sale Equity [Abstract] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Common stock, shares issued (in shares) Common Stock, Shares, Issued Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Schedule of Stock by Class [Table] Schedule of Stock by Class [Table] Class of Stock [Line Items] Class of Stock [Line Items] Warrants exercised, number of shares represented (as shares) Class Of Warrant Or Right, Number Of Securities Called By Warrants Or Rights Exercised Class Of Warrant Or Right, Number Of Securities Called By Warrants Or Rights Exercised Warrants exercised, number of shares represented, cashless exercise (as shares) Class Of Warrant Or Right, Number Of Securities Called By Warrants Or Rights Exercised, Non-cash Exercise Class Of Warrant Or Right, Number Of Securities Called By Warrants Or Rights Exercised, Non-cash Exercise Shares issued as a result of warrants exercised (in shares) Stock Issued During Period, Shares, Issued For Warrants Stock Issued During Period, Shares, Issued For Warrants Repurchase of shares (in shares) Stock Repurchased During Period, Shares Components of income/(loss) before income tax provision (benefit) Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Schedule of components of deferred tax assets and liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Reconciliation of expected statutory federal income tax provision and actual income tax provision Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Schedule of activity related to unrecognized tax benefits Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Research and development Research and Development Expense [Member] General and administrative General and Administrative Expense [Member] Income Statement [Abstract] Collaboration revenue Revenue from Contract with Customer, Including Assessed Tax Operating expenses: Operating Expenses [Abstract] Research and development Research and Development Expense General and administrative General and Administrative Expense Total operating expenses Operating Expenses Loss from operations Other income (expense), net: Nonoperating Income (Expense) [Abstract] Interest expense Interest Expense Change in fair value of liability for preferred stock warrants Interest income Interest Income, Other Other (expense) income, net Other Nonoperating Income (Expense) Total other income (expense), net Nonoperating Income (Expense) Loss before income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Provision for income taxes Income Tax Expense (Benefit) Net loss Other comprehensive income (loss): Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Unrealized income (loss) on available for sale securities Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, before Tax Income tax expense related to other comprehensive income Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, Tax Other comprehensive income (loss), net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Net loss per common share: Basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Weighted-average number of shares outstanding: Earnings Per Share, Basic and Diluted, Other Disclosures [Abstract] Basic and diluted (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Accrued compensation and related expenses Employee-related Liabilities, Current Accrued research and contract manufacturing expenses Accrued Research And Contract Manufacturing Expenses, Current Accrued Research And Contract Manufacturing Expenses, Current Other Other Accrued Liabilities, Current Total accrued expenses Issued and Outstanding: Common Stock, Number of Shares, Par Value and Other Disclosures [Abstract] Stock options (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Shares reserved for future award grants (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant Common stock, shares reserved for issuance (in shares) Common Stock, Capital Shares Reserved for Future Issuance Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Basis of Consolidation Consolidation, Policy [Policy Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Short Term and Long Term Investments Marketable Securities, Policy [Policy Text Block] Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Long Lived Assets Property, Plant and Equipment, Impairment [Policy Text Block] Leases, Deferred Rent and Operating Lease Incentives Lessee, Leases [Policy Text Block] Debt Issuance Costs Debt, Policy [Policy Text Block] Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Research and Development Research and Development Expense, Policy [Policy Text Block] Share-Based Compensation Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Warrants for Shares of Preferred Stock Derivatives, Policy [Policy Text Block] Income Taxes Income Tax, Policy [Policy Text Block] Foreign Currency of Foreign Operations Foreign Currency Transactions and Translations Policy [Policy Text Block] Comprehensive Loss Comprehensive Income, Policy [Policy Text Block] Net Loss Per Common Share Earnings Per Share, Policy [Policy Text Block] Accounting Pronouncements Recently Adopted and Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Property and Equipment Property, Plant and Equipment [Table Text Block] Schedule of Accrued Expenses Schedule of Accrued Liabilities [Table Text Block] Selected Quarterly Financial Data (Unaudited) Quarterly Financial Information [Text Block] Shares Subject to Options Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Stock options outstanding, beginning balance (in shares) Exercises (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Forfeitures and cancellations (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period Stock options outstanding, ending balance (in shares) Stock options exercisable, ending balance (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Weighted-Average Exercise Price per Share Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Stock options outstanding, beginning balance (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Exercises (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Forfeitures and cancellations (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Stock options outstanding, ending balance (in dollars per share) Stock options exercisable, ending balance (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted-Average Remaining Contractual Term and Aggregate Intrinsic Value Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Weighted average remaining contractual term, options outstanding (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Weighted average remaining contractual term, options exercisable (in years) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Aggregate intrinsic value, options outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Aggregate intrinsic value, options exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value Income Taxes Income Tax Disclosure [Text Block] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-sale [Line Items] Amortized Cost Debt Securities, Available-for-sale, Amortized Cost Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Gross Unrealized Losses Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Remaining maturity Available-for-sale Debt Securities, Remaining Maturity Available-for-sale Debt Securities, Remaining Maturity Revenue Recognition [Abstract] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Schedule of Collaborative Arrangements and Non-collaborative Arrangement Transactions [Table] Counterparty Name [Axis] Counterparty Name [Axis] Counterparty Name [Domain] Counterparty Name [Domain] TESARO TESARO, Inc. And TESARO Development, Inc. [Member] TESARO, Inc. And TESARO Development, Inc. 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