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Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2203201 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2304301 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2405401 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Summary of Significant Accounting Policies - Summary of Potentially Dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2107103 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures link:presentationLink link:calculationLink link:definitionLink 2308302 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures (Tables) link:presentationLink link:calculationLink link:definitionLink 2409403 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2410404 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 2111104 - Disclosure - Collaborative Research and Development Agreements link:presentationLink link:calculationLink link:definitionLink 2312303 - Disclosure - Collaborative Research and Development Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2413405 - Disclosure - Collaborative Research and Development Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2114105 - Disclosure - Notes Payable link:presentationLink link:calculationLink link:definitionLink 2415406 - Disclosure - Notes Payable (Details) link:presentationLink link:calculationLink link:definitionLink 2116106 - Disclosure - Fair Value Measurements and Available for Sale Investments link:presentationLink link:calculationLink link:definitionLink 2317304 - Disclosure - Fair Value Measurements and Available for Sale Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 2418407 - Disclosure - Fair Value Measurements and Available for Sale Investments - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 2419408 - Disclosure - Fair Value Measurements and Available for Sale Investments - Fair Value of Other Financial Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 2420409 - Disclosure - Fair Value Measurements and Available for Sale Investments - Available-for-sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 2421410 - Disclosure - Fair Value Measurements and Available for Sale Investments - Schedule of Unrealized Loss and Fair Values in a Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 2122107 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 2323305 - 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Disclosure - Equity Incentive Plans - Allocation of Share-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2132109 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2333307 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 2434417 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2435418 - Disclosure - Commitments and Contingencies - Classification on the Balance Sheet (Details) link:presentationLink link:calculationLink link:definitionLink 2436419 - Disclosure - Commitments and Contingencies - Costs Included in Cash Flow Statement (Details) link:presentationLink link:calculationLink link:definitionLink 2437420 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 2437420 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink