0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statement of Stockholders’ Equity link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Description of the Business link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Collaborative Research and Development Agreements link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value Measurements and Available for Sale Investments link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Equity Incentive Plans link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Collaborative Research and Development Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Sale of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Fair Value Measurements and Available for Sale Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Equity Incentive Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Segment Reporting (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Summary of Significant Accounting Policies - Schedule of Outstanding Potentially Dilutive Securities Excluded in the Calculation of Diluted Net Loss Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Schedule of Property and Equipment, net (Details) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures -Schedule of Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Collaborative Research and Development Agreements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Collaborative Research and Development Agreements - Schedule of Milestone Achieved (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Sale of Future Royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Sale of Future Royalties - Schedule of Royalty Transaction Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Fair Value Measurements and Available for Sale Investments - Schedule of Assets and Liabilities that Require Fair Value Measurements on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Fair Value Measurements and Available for Sale Investments -Schedule of Available-for-sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Fair Value Measurements and Available for Sale Investments - Schedule of Unrealized Loss and Fair Values in a Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Fair Value Measurements and Available for Sale Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stockholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Stockholders' Equity - Schedule of Stock Repurchase Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Equity Incentive Plans - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Equity Incentive Plans -Schedule of Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Equity Incentive Plans - Schedule of Time-based Restricted Stock Units & PSU's (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Equity Incentive Plans - Schedule of Grant Date Fair Value Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Equity Incentive Plans - Schedule of Weighted Average Assumptions used to Estimate Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Equity Incentive Plans -Schedule of Non-cash Stock-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Commitments and Contingencies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Commitments and Contingencies - Schedule of Non-Cancellable Office Lease Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Segment Reporting - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Segment Reporting - Schedule of Segment Revenue, Loss and Significant Expenses (Details) link:presentationLink link:calculationLink link:definitionLink