<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:e5df94b1-aa50-4e85-b999-bd6f574d389b,g:02327c66-1ab8-49d0-b9de-b9f7fcd91ac9-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CoverPage" xlink:type="simple" xlink:href="anab-20200720.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_9fff9c93-a567-4324-9fdc-04900a0a9b2a" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_DocumentType_9fff9c93-a567-4324-9fdc-04900a0a9b2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_cb93358b-132d-4719-9b33-56325fc92bfc" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_DocumentPeriodEndDate_cb93358b-132d-4719-9b33-56325fc92bfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_1c50a5ac-8557-4ea2-9878-48c871618b97" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityRegistrantName_1c50a5ac-8557-4ea2-9878-48c871618b97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_4a044321-7ca3-4a5c-b917-fe13c89778d2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityIncorporationStateCountryCode_4a044321-7ca3-4a5c-b917-fe13c89778d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_62fe4625-0f6c-4e88-9123-b3adfb00f07c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityFileNumber_62fe4625-0f6c-4e88-9123-b3adfb00f07c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_4d0de4bc-9b2f-4d50-bbe9-cfa19f19eeb9" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityTaxIdentificationNumber_4d0de4bc-9b2f-4d50-bbe9-cfa19f19eeb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_ecb43067-89a2-4ae8-8ebb-e075950e44b4" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityAddressAddressLine1_ecb43067-89a2-4ae8-8ebb-e075950e44b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_3c732a21-63ee-4dfe-9bc8-542eb798340f" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityAddressAddressLine2_3c732a21-63ee-4dfe-9bc8-542eb798340f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_594722ef-d473-45c1-a787-0b00be44a420" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityAddressCityOrTown_594722ef-d473-45c1-a787-0b00be44a420" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_d0ab7507-6125-418a-b55f-9d003e55315e" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityAddressStateOrProvince_d0ab7507-6125-418a-b55f-9d003e55315e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_3f7f9226-1ae8-4741-8102-0cb9a5466cbd" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityAddressPostalZipCode_3f7f9226-1ae8-4741-8102-0cb9a5466cbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_db36a6e7-ff48-4712-81a1-b93bff0f5187" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_CityAreaCode_db36a6e7-ff48-4712-81a1-b93bff0f5187" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_718fb9d2-6c3e-470f-b775-8804844dc8c6" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_LocalPhoneNumber_718fb9d2-6c3e-470f-b775-8804844dc8c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_02ff68e8-982e-49f9-b539-5ab27b6f86cc" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_WrittenCommunications_02ff68e8-982e-49f9-b539-5ab27b6f86cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_55d27fa6-fbce-4f56-89a3-e7838060ae41" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_SolicitingMaterial_55d27fa6-fbce-4f56-89a3-e7838060ae41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_e0ed1f45-b36a-40e5-8d6d-281d6a0e5f2b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_PreCommencementTenderOffer_e0ed1f45-b36a-40e5-8d6d-281d6a0e5f2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_25a0770e-3de2-4f55-bd61-059dd90cb739" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_25a0770e-3de2-4f55-bd61-059dd90cb739" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_a323d71b-ec1e-4db5-88be-8f216157037b" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_Security12bTitle_a323d71b-ec1e-4db5-88be-8f216157037b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_aa5ae9b4-0f5f-4941-9817-7106d7f14f77" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_TradingSymbol_aa5ae9b4-0f5f-4941-9817-7106d7f14f77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_6750b984-f9c9-47a1-9578-17d381c93190" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_SecurityExchangeName_6750b984-f9c9-47a1-9578-17d381c93190" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_acae42f3-1614-4300-9121-2cd3ac1d5e73" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityEmergingGrowthCompany_acae42f3-1614-4300-9121-2cd3ac1d5e73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5e18b400-8648-47fd-bf46-d3c6efbe47b6" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_EntityCentralIndexKey_5e18b400-8648-47fd-bf46-d3c6efbe47b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_3b3a2a54-70fb-44d4-a8bc-31ba87e4336a" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_78385dfe-93e5-43d2-b9c2-80f95e436b1e" xlink:to="loc_dei_AmendmentFlag_3b3a2a54-70fb-44d4-a8bc-31ba87e4336a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
