<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2020 Workiva-->
<!--r:fa8f6103-30b7-402e-85c5-4e422811592c,g:4854a8f1-3c06-494a-a152-c3d699a87ff2-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CoverPage" xlink:type="simple" xlink:href="anab-20201013.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_7467a3bb-8e2a-4164-b5ee-bc59ea5c033a" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_DocumentType_7467a3bb-8e2a-4164-b5ee-bc59ea5c033a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_1a4b4865-5a49-4806-94ea-ee5bb8e02c52" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_DocumentPeriodEndDate_1a4b4865-5a49-4806-94ea-ee5bb8e02c52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_49c21560-3309-4849-88db-5ed684ff778d" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityRegistrantName_49c21560-3309-4849-88db-5ed684ff778d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_c6980634-b740-4c58-9b87-87aaa386b976" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityIncorporationStateCountryCode_c6980634-b740-4c58-9b87-87aaa386b976" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_79b3f7e2-e015-4348-bc7d-bdc7149222da" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityFileNumber_79b3f7e2-e015-4348-bc7d-bdc7149222da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_8a278d0e-8d78-4c3f-88e7-45cded8a1f02" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityTaxIdentificationNumber_8a278d0e-8d78-4c3f-88e7-45cded8a1f02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_3d1213af-7e87-490e-a9a7-3995dc738608" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityAddressAddressLine1_3d1213af-7e87-490e-a9a7-3995dc738608" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_7fdbfd75-1d94-49dd-bd21-448c0042328c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityAddressAddressLine2_7fdbfd75-1d94-49dd-bd21-448c0042328c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_14afe968-1bdc-40e1-bf55-53aa3cb0ee79" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityAddressCityOrTown_14afe968-1bdc-40e1-bf55-53aa3cb0ee79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_06bca51e-f13a-4da4-b6f9-7ea4b3b29452" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityAddressStateOrProvince_06bca51e-f13a-4da4-b6f9-7ea4b3b29452" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_201948ed-5ec0-4960-82c3-687141ddf6bb" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityAddressPostalZipCode_201948ed-5ec0-4960-82c3-687141ddf6bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_c37d641d-4bbe-406d-af29-01b1843c9c86" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_CityAreaCode_c37d641d-4bbe-406d-af29-01b1843c9c86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_251f769d-3199-4ae8-a1c1-1240b97ffe95" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_LocalPhoneNumber_251f769d-3199-4ae8-a1c1-1240b97ffe95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_705e4ce6-04bf-4d88-a189-7107199d8c59" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_WrittenCommunications_705e4ce6-04bf-4d88-a189-7107199d8c59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_3694133e-0c0b-4083-834a-a7559a7351e8" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_SolicitingMaterial_3694133e-0c0b-4083-834a-a7559a7351e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_89a1a702-ea2a-42c5-907d-1a22d7c2e412" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_PreCommencementTenderOffer_89a1a702-ea2a-42c5-907d-1a22d7c2e412" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_23755a0c-4dee-4711-9f05-e499b17c7f20" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_23755a0c-4dee-4711-9f05-e499b17c7f20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_397092cd-c096-41e9-b0f0-1b927950e4bb" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_Security12bTitle_397092cd-c096-41e9-b0f0-1b927950e4bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_81ca3e07-79c5-438b-b9e5-d7d51f6ed06c" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_TradingSymbol_81ca3e07-79c5-438b-b9e5-d7d51f6ed06c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_315a48b9-2891-4adb-aaa0-009a37d89517" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_SecurityExchangeName_315a48b9-2891-4adb-aaa0-009a37d89517" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_0392eaad-56d9-45e1-8258-dd5b6f922817" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityEmergingGrowthCompany_0392eaad-56d9-45e1-8258-dd5b6f922817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b660b6b1-03bf-4441-b269-b9aa1697e0c2" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_EntityCentralIndexKey_b660b6b1-03bf-4441-b269-b9aa1697e0c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_da70b234-ab17-4e33-9563-f04246e05554" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_AmendmentFlag_da70b234-ab17-4e33-9563-f04246e05554" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_e776b0c8-efa2-4c4b-abe9-a997f5a02a42" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_40e79110-e2f4-4706-b0f0-4abf4c3cbe11" xlink:to="loc_dei_DocumentInformationTable_e776b0c8-efa2-4c4b-abe9-a997f5a02a42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_986c0b54-3883-43ab-a08b-8a01a092e749" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_e776b0c8-efa2-4c4b-abe9-a997f5a02a42" xlink:to="loc_dei_DocumentInformationLineItems_986c0b54-3883-43ab-a08b-8a01a092e749" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_9e5aa4e4-335f-4e07-bac8-41c8c7124d48" xlink:href="https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_986c0b54-3883-43ab-a08b-8a01a092e749" xlink:to="loc_dei_DocumentType_9e5aa4e4-335f-4e07-bac8-41c8c7124d48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
