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  <xs:element id="anab_FirstCommercialSalesMilestoneMember" abstract="true" name="FirstCommercialSalesMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_RevenueRecognitionMilestoneMethodNumberOfMilestonesAchievedDuringPeriod" abstract="false" name="RevenueRecognitionMilestoneMethodNumberOfMilestonesAchievedDuringPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="anab_FourthCommercialSalesMilestoneMember" abstract="true" name="FourthCommercialSalesMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesAggregatePaymentThresholdPercent" abstract="false" name="AdvanceFutureRoyaltiesAggregatePaymentThresholdPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingNumber" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="anab_Phase3ClinicalTrialInitiationSecondIndicationMember" abstract="true" name="Phase3ClinicalTrialInitiationSecondIndicationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_SaleOfFutureRoyaltiesTextBlockTextBlock" abstract="false" name="SaleOfFutureRoyaltiesTextBlockTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward" abstract="true" name="LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="anab_SagardHealthcareRoyaltyPartnersLPMember" abstract="true" name="SagardHealthcareRoyaltyPartnersLPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_RevenueRecognitionMilestoneMethodContingent" abstract="false" name="RevenueRecognitionMilestoneMethodContingent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_Phase3ClinicalTrialInitiationFirstIndicationMember" abstract="true" name="Phase3ClinicalTrialInitiationFirstIndicationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardCommonShareEquivalent" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardCommonShareEquivalent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesEffectiveRoyaltyRate" abstract="false" name="AdvanceFutureRoyaltiesEffectiveRoyaltyRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anab_ClearanceOfInvestigationalNewDrugFromFDAMember" abstract="true" name="ClearanceOfInvestigationalNewDrugFromFDAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_RoyaltyAgreementUpTo10BillionMember" abstract="true" name="RoyaltyAgreementUpTo10BillionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_InterimPresidentAndChiefExecutiveOfficerMember" abstract="true" name="InterimPresidentAndChiefExecutiveOfficerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_RentPerSquareFoot" abstract="false" name="RentPerSquareFoot" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="srt-types:perUnitItemType"/>
  <xs:element id="anab_FilingOfMMAFirstIndicationMember" abstract="true" name="FilingOfMMAFirstIndicationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesAnnualSalesThreshold" abstract="false" name="AdvanceFutureRoyaltiesAnnualSalesThreshold" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_AccruedCommonStockRepurchased" abstract="false" name="AccruedCommonStockRepurchased" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable" abstract="true" name="LiabilitiesRelatedToSaleOfFutureRoyaltiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesIssuanceCosts" abstract="false" name="AdvanceFutureRoyaltiesIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_RepaymentOfAdvanceFutureRoyaltyAndMilestones" abstract="false" name="RepaymentOfAdvanceFutureRoyaltyAndMilestones" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_NoncashAdvanceFutureRoyaltiesIssuanceCostsIncurredButNotYetPaid" abstract="false" name="NoncashAdvanceFutureRoyaltiesIssuanceCostsIncurredButNotYetPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesInterestRateEffectivePercentage" abstract="false" name="AdvanceFutureRoyaltiesInterestRateEffectivePercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="anab_AdvanceFutureRoyaltiesLiabilityNoncurrent" abstract="false" name="AdvanceFutureRoyaltiesLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="anab_AvailableforsaleDebtSecuritiesRemainingMaturity" abstract="false" name="AvailableforsaleDebtSecuritiesRemainingMaturity" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEmployeeStockPurchasePlan" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEmployeeStockPurchasePlan" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
</xs:schema>
