<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:1426b0b8-c0e7-4c33-a5ad-cd68e66dfa33,g:5c4e3f35-51be-4700-be6f-c394b2db858d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CoverPage" xlink:type="simple" xlink:href="anab-20220630.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_c1faafbe-1bf3-4b9e-8aed-deb45b0f0b0c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentType_c1faafbe-1bf3-4b9e-8aed-deb45b0f0b0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_06f95a95-bf09-4be2-8287-a70579b24b72" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentQuarterlyReport_06f95a95-bf09-4be2-8287-a70579b24b72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_ba259224-4c76-41b1-a734-a797c2a0b65e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentPeriodEndDate_ba259224-4c76-41b1-a734-a797c2a0b65e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_b03cde93-ebc0-4a49-90f4-23dfe7199817" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentTransitionReport_b03cde93-ebc0-4a49-90f4-23dfe7199817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_cf40da9d-4ba8-47a3-899e-e4ad1c17279f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityFileNumber_cf40da9d-4ba8-47a3-899e-e4ad1c17279f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_495329ac-1105-421b-8fea-9d7923e9c408" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityRegistrantName_495329ac-1105-421b-8fea-9d7923e9c408" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_bd8b8da5-2f5e-403e-add0-7c4358ec7439" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityIncorporationStateCountryCode_bd8b8da5-2f5e-403e-add0-7c4358ec7439" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_21c09e3a-948a-4cfd-bba8-890a2cac8f01" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityTaxIdentificationNumber_21c09e3a-948a-4cfd-bba8-890a2cac8f01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_99ec3f6e-d6e7-45ac-9a4c-1288ebd51e4f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityAddressAddressLine1_99ec3f6e-d6e7-45ac-9a4c-1288ebd51e4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_676a30c6-ebef-4bce-ae4a-fee752476b86" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityAddressAddressLine2_676a30c6-ebef-4bce-ae4a-fee752476b86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_b5588aa8-ddd4-4d63-b5eb-3f1723791e94" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityAddressCityOrTown_b5588aa8-ddd4-4d63-b5eb-3f1723791e94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_9f96de8a-560b-4806-bc1a-b0002fb2d3ea" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityAddressStateOrProvince_9f96de8a-560b-4806-bc1a-b0002fb2d3ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_be9fe463-69f6-4d38-9d38-3c6f65612de9" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityAddressPostalZipCode_be9fe463-69f6-4d38-9d38-3c6f65612de9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_0244e2a5-1b1b-4334-84d7-ef45ddcc13f9" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_CityAreaCode_0244e2a5-1b1b-4334-84d7-ef45ddcc13f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_d59f1a92-c312-4787-a851-1a64f6734213" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_LocalPhoneNumber_d59f1a92-c312-4787-a851-1a64f6734213" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_ccd7e57b-b827-4cf5-a9b3-a33ad7688d71" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_Security12bTitle_ccd7e57b-b827-4cf5-a9b3-a33ad7688d71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_2449a236-4837-45d5-846c-5e0eed2abdaf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_TradingSymbol_2449a236-4837-45d5-846c-5e0eed2abdaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_292f648a-a791-43c0-a57a-b468b2390fe6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_SecurityExchangeName_292f648a-a791-43c0-a57a-b468b2390fe6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_9bc06da9-bed2-4936-afdb-de9c222a333a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityCurrentReportingStatus_9bc06da9-bed2-4936-afdb-de9c222a333a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_1682d012-dba8-4a73-b0cb-c752e0d486e1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityInteractiveDataCurrent_1682d012-dba8-4a73-b0cb-c752e0d486e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_cd055c81-a6f2-4cb9-b35b-7955f9bfc598" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityFilerCategory_cd055c81-a6f2-4cb9-b35b-7955f9bfc598" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_44e26624-4510-44c7-8a30-736e8d15d960" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntitySmallBusiness_44e26624-4510-44c7-8a30-736e8d15d960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_cae7e283-cdde-4159-baa0-888abb1008b6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityEmergingGrowthCompany_cae7e283-cdde-4159-baa0-888abb1008b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_a27ed54a-fe02-402d-a998-00b172076261" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityShellCompany_a27ed54a-fe02-402d-a998-00b172076261" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_c744f587-9402-471e-b9ca-c83c01e1ea20" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_c744f587-9402-471e-b9ca-c83c01e1ea20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_b5fcd06f-13f8-49b2-807f-9d95704c54ab" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_EntityCentralIndexKey_b5fcd06f-13f8-49b2-807f-9d95704c54ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_affcf5a8-01c9-4342-b0bd-b26c29e4733d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_CurrentFiscalYearEndDate_affcf5a8-01c9-4342-b0bd-b26c29e4733d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_b0919be2-f4c7-4afa-96cf-7e3d1a0ce86c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentFiscalYearFocus_b0919be2-f4c7-4afa-96cf-7e3d1a0ce86c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_8e229d30-372c-44bd-b883-3d16cfd1af56" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_DocumentFiscalPeriodFocus_8e229d30-372c-44bd-b883-3d16cfd1af56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_0ebd0699-0f8c-44f2-82d1-3005172f3f22" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6f160a83-9fb1-4c49-882a-4eaa2a95adb2" xlink:to="loc_dei_AmendmentFlag_0ebd0699-0f8c-44f2-82d1-3005172f3f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="anab-20220630.xsd#ConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_17fa11ec-ee53-438b-9dfd-4d1852fc9597" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_17fa11ec-ee53-438b-9dfd-4d1852fc9597" xlink:to="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_5ec771ff-c428-4bcf-a197-58aa8e407932" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_5ec771ff-c428-4bcf-a197-58aa8e407932" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_76f28436-ca86-4e83-a970-b241964b5ae4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:to="loc_us-gaap_ReceivablesNetCurrent_76f28436-ca86-4e83-a970-b241964b5ae4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_85b88e30-29a9-40e3-a99b-c01d5ce2cfb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_85b88e30-29a9-40e3-a99b-c01d5ce2cfb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fc190529-89b9-4645-96ee-5282f7009f12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_fc190529-89b9-4645-96ee-5282f7009f12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_65731964-2e6d-49f7-8293-e28fe2f0c2fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_9a1afb1c-cfb6-4b6d-b3e5-fd31b13247ac" xlink:to="loc_us-gaap_AssetsCurrent_65731964-2e6d-49f7-8293-e28fe2f0c2fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_e0bd72aa-0eda-4a67-b8dd-a966fd5535b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_e0bd72aa-0eda-4a67-b8dd-a966fd5535b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_9478199f-e679-40a3-a89b-e61629b3567f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_9478199f-e679-40a3-a89b-e61629b3567f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_0cd1fe3e-2564-478b-8acf-f9ff5ef01a7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_0cd1fe3e-2564-478b-8acf-f9ff5ef01a7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_3efbeb31-c822-47b5-b659-355ae45f3bc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_3efbeb31-c822-47b5-b659-355ae45f3bc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_30ab3ccf-691a-44d3-828d-586f47750e87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_69372e40-acf9-4415-b815-a176c4689f00" xlink:to="loc_us-gaap_Assets_30ab3ccf-691a-44d3-828d-586f47750e87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_17fa11ec-ee53-438b-9dfd-4d1852fc9597" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_1bc0e483-37c2-4c36-9258-7b18c8f6f9cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:to="loc_us-gaap_AccountsPayableCurrent_1bc0e483-37c2-4c36-9258-7b18c8f6f9cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_7c282916-2ea6-473f-951c-cab1717c0db9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_7c282916-2ea6-473f-951c-cab1717c0db9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_1134ed53-63d7-4277-ad9c-c4520aa6890d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_1134ed53-63d7-4277-ad9c-c4520aa6890d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_59d80068-d868-4098-b2d3-166dabe524dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_95280f42-8aca-4785-a8d5-2546fce5c1b5" xlink:to="loc_us-gaap_LiabilitiesCurrent_59d80068-d868-4098-b2d3-166dabe524dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_5635d0cb-b680-4ef4-acf5-f0090498f3b1" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:to="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_5635d0cb-b680-4ef4-acf5-f0090498f3b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b5823d24-4395-4de9-bb65-84e1daf74edc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_b5823d24-4395-4de9-bb65-84e1daf74edc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:to="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_194ad6d1-4761-459f-98aa-2c14714e225b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_PreferredStockValue_194ad6d1-4761-459f-98aa-2c14714e225b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_a4a8951a-91fe-4a56-b518-5117d12305dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_CommonStockValue_a4a8951a-91fe-4a56-b518-5117d12305dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_44c85d9b-d828-4693-b7c3-d7a89f257920" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_AdditionalPaidInCapital_44c85d9b-d828-4693-b7c3-d7a89f257920" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b773a60f-ba85-47aa-9afb-3a5a5935f798" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b773a60f-ba85-47aa-9afb-3a5a5935f798" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d652c95c-c539-44f2-b063-fb35664d4649" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d652c95c-c539-44f2-b063-fb35664d4649" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3bf1b740-40c4-4b46-a76b-90f3746ad9ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_7df5581d-6d31-4aab-b1f9-726945deb080" xlink:to="loc_us-gaap_StockholdersEquity_3bf1b740-40c4-4b46-a76b-90f3746ad9ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_3c04e653-93e0-49ac-8bda-15a0f484c979" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_d13812a2-7799-4711-ad4b-5182f7392dc0" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_3c04e653-93e0-49ac-8bda-15a0f484c979" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="anab-20220630.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3248fff9-8fcb-4833-a9d7-e6573b427cae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_3248fff9-8fcb-4833-a9d7-e6573b427cae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_53679814-ac09-42a0-97ce-005c86a5461f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_53679814-ac09-42a0-97ce-005c86a5461f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_bff1ac00-cd04-4bdb-b3df-b8950f01bc7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_PreferredStockSharesIssued_bff1ac00-cd04-4bdb-b3df-b8950f01bc7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_d7a16ddc-f6a2-4134-b243-9875f28ea6ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_d7a16ddc-f6a2-4134-b243-9875f28ea6ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_d4c9d6c8-af4a-42c5-8970-64af6d21d838" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_d4c9d6c8-af4a-42c5-8970-64af6d21d838" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_4b12fc67-69aa-4820-b277-f352af2eb1fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_4b12fc67-69aa-4820-b277-f352af2eb1fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_549ce2b1-eb12-490e-94d6-c634397211ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_CommonStockSharesIssued_549ce2b1-eb12-490e-94d6-c634397211ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_60c76db4-239b-4d3b-91ea-6b16c91dd6f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5dc09f3a-1ff2-4a2d-b649-81d30f597d5c" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_60c76db4-239b-4d3b-91ea-6b16c91dd6f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="simple" xlink:href="anab-20220630.xsd#ConsolidatedStatementsofOperationsandComprehensiveLoss"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedStatementsofOperationsandComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_40f9ee49-65e0-4f1d-bd61-8720165a4fc8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_40f9ee49-65e0-4f1d-bd61-8720165a4fc8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_30eeced2-5249-4786-b5f3-a19503c86b5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_OperatingExpensesAbstract_30eeced2-5249-4786-b5f3-a19503c86b5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_89d6355f-4788-4ee2-be1c-18d7205d1679" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_30eeced2-5249-4786-b5f3-a19503c86b5d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_89d6355f-4788-4ee2-be1c-18d7205d1679" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_ed9fadb2-f3a4-4abf-8d5f-acab3b73d55f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_30eeced2-5249-4786-b5f3-a19503c86b5d" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_ed9fadb2-f3a4-4abf-8d5f-acab3b73d55f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_c4d56206-80ee-4139-8b02-74bad856b77d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_30eeced2-5249-4786-b5f3-a19503c86b5d" xlink:to="loc_us-gaap_OperatingExpenses_c4d56206-80ee-4139-8b02-74bad856b77d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8159b416-5bcc-495e-8499-aa014114d075" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_OperatingIncomeLoss_8159b416-5bcc-495e-8499-aa014114d075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeOther_98df4c2e-4970-42f2-a5e8-87ed372a44ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeOther"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:to="loc_us-gaap_InterestIncomeOther_98df4c2e-4970-42f2-a5e8-87ed372a44ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesInterestExpense_f1ab0286-742e-478c-ad9e-b67e514e3a58" xlink:href="anab-20220630.xsd#anab_NoncashAdvanceFutureRoyaltiesInterestExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesInterestExpense_f1ab0286-742e-478c-ad9e-b67e514e3a58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_5fc89b5f-3adf-4d93-8b5a-7e21c6540f9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_5fc89b5f-3adf-4d93-8b5a-7e21c6540f9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_16f51d74-67e8-445e-9bf3-4b2cad3ad5ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_d602f7f3-f9a2-41a3-81f9-b0ae8d8f019e" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_16f51d74-67e8-445e-9bf3-4b2cad3ad5ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9504809b-f303-45e9-9a17-4f55e467fe04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_NetIncomeLoss_9504809b-f303-45e9-9a17-4f55e467fe04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_397ce88e-32f6-4eac-b518-a93632a3abf0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_397ce88e-32f6-4eac-b518-a93632a3abf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_bab1e6ac-ae7d-4936-b39a-3ab4936b5e5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_bab1e6ac-ae7d-4936-b39a-3ab4936b5e5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareAbstract_7adec64a-a983-40fb-b9c1-11fa31a6b8e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_EarningsPerShareAbstract_7adec64a-a983-40fb-b9c1-11fa31a6b8e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_cb33e8f4-eff9-47e5-a8dc-7dc497ca1e91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7adec64a-a983-40fb-b9c1-11fa31a6b8e7" xlink:to="loc_us-gaap_EarningsPerShareBasic_cb33e8f4-eff9-47e5-a8dc-7dc497ca1e91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_a69a86ff-08d0-4d9f-8f56-1bd213c19f32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_7adec64a-a983-40fb-b9c1-11fa31a6b8e7" xlink:to="loc_us-gaap_EarningsPerShareDiluted_a69a86ff-08d0-4d9f-8f56-1bd213c19f32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_d87e2c1e-ce37-40e3-89a8-305be40ae6f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_d87e2c1e-ce37-40e3-89a8-305be40ae6f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_19054b6a-769d-4fb0-a995-2fea797fe151" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_d87e2c1e-ce37-40e3-89a8-305be40ae6f6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_19054b6a-769d-4fb0-a995-2fea797fe151" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ba90f2b5-4c2f-4712-ab62-99f95cf759c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_d87e2c1e-ce37-40e3-89a8-305be40ae6f6" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_ba90f2b5-4c2f-4712-ab62-99f95cf759c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerProductAndServiceExtensibleList_473ad760-e63f-4820-a3ca-390fb3573ab5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerProductAndServiceExtensibleList"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_9c214ba3-c2b9-4d59-891f-9fceb7d4eed5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerProductAndServiceExtensibleList_473ad760-e63f-4820-a3ca-390fb3573ab5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="simple" xlink:href="anab-20220630.xsd#ConsolidatedStatementofStockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedStatementofStockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_10c581a0-ff8e-4760-88cc-575d28428de3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_8019c753-6cc4-42f3-88c4-855aa29bed24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_10c581a0-ff8e-4760-88cc-575d28428de3" xlink:to="loc_us-gaap_StatementTable_8019c753-6cc4-42f3-88c4-855aa29bed24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_59e9cd9a-b6ca-4f03-9aaf-1cb2de10552f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8019c753-6cc4-42f3-88c4-855aa29bed24" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_59e9cd9a-b6ca-4f03-9aaf-1cb2de10552f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_59e9cd9a-b6ca-4f03-9aaf-1cb2de10552f" xlink:to="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_e793a775-f4a8-4ae6-9c66-ff4bddf2efb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:to="loc_us-gaap_CommonStockMember_e793a775-f4a8-4ae6-9c66-ff4bddf2efb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_8fa384b0-3f49-4041-87f6-86275c798760" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_8fa384b0-3f49-4041-87f6-86275c798760" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94204cf9-da6d-42fc-95e4-7a1d8a89005e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94204cf9-da6d-42fc-95e4-7a1d8a89005e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_473d89f3-5ad0-4f86-bf7f-02382091e5b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_0e4fcf40-8a76-4277-b25a-29aece21e454" xlink:to="loc_us-gaap_RetainedEarningsMember_473d89f3-5ad0-4f86-bf7f-02382091e5b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_23ff6189-298b-451c-ae9b-a78acf6a626b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_8019c753-6cc4-42f3-88c4-855aa29bed24" xlink:to="loc_us-gaap_StatementLineItems_23ff6189-298b-451c-ae9b-a78acf6a626b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_23ff6189-298b-451c-ae9b-a78acf6a626b" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_134d027a-ba9b-41d4-b5df-d5376a75d91b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_SharesOutstanding_134d027a-ba9b-41d4-b5df-d5376a75d91b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7ee5414e-f8d4-4233-a7bb-8a0e609b5bd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_StockholdersEquity_7ee5414e-f8d4-4233-a7bb-8a0e609b5bd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEmployeeStockPurchasePlan_77ad1e25-58ff-45e7-a58c-6207002668ac" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEmployeeStockPurchasePlan"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEmployeeStockPurchasePlan_77ad1e25-58ff-45e7-a58c-6207002668ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_StockIssuedDuringPeriodValueOptionsAndEmployeeStockPurchasePlan_59740866-7d8d-4598-93b9-7dd4a0f4f9d5" xlink:href="anab-20220630.xsd#anab_StockIssuedDuringPeriodValueOptionsAndEmployeeStockPurchasePlan"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_anab_StockIssuedDuringPeriodValueOptionsAndEmployeeStockPurchasePlan_59740866-7d8d-4598-93b9-7dd4a0f4f9d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_08bb8ed4-776b-4507-86f3-c4f09261be89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_08bb8ed4-776b-4507-86f3-c4f09261be89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_442aa919-83cc-4f00-b7e4-3539fc8c374e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_442aa919-83cc-4f00-b7e4-3539fc8c374e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition_6cac54e1-9a15-4b7f-bddb-c3e65a8eedc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition_6cac54e1-9a15-4b7f-bddb-c3e65a8eedc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_eb9627cb-2ae4-400f-bf18-e36dbbac04de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_eb9627cb-2ae4-400f-bf18-e36dbbac04de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_22dc8699-510b-4ba7-86fe-a8de96e14cb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_NetIncomeLoss_22dc8699-510b-4ba7-86fe-a8de96e14cb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_f6016ed4-4946-447c-8a00-ae7cdab82c73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_SharesOutstanding_f6016ed4-4946-447c-8a00-ae7cdab82c73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_32941b53-6797-462a-a396-b06acf73a68b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_ee7fb2fd-87fd-4df7-bd0d-e50f78da01c2" xlink:to="loc_us-gaap_StockholdersEquity_32941b53-6797-462a-a396-b06acf73a68b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="anab-20220630.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_41ba4cf8-e577-4e8a-8f4f-e10c3e733c7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_41ba4cf8-e577-4e8a-8f4f-e10c3e733c7c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c6685cad-5db7-4f29-a76c-3b57cf3ce324" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_41ba4cf8-e577-4e8a-8f4f-e10c3e733c7c" xlink:to="loc_us-gaap_NetIncomeLoss_c6685cad-5db7-4f29-a76c-3b57cf3ce324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_41ba4cf8-e577-4e8a-8f4f-e10c3e733c7c" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_2b7d6d4d-7ec2-4eca-9396-a86cc4a7ee0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_2b7d6d4d-7ec2-4eca-9396-a86cc4a7ee0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_3f24244e-8327-488d-9fcc-290e61220905" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_ShareBasedCompensation_3f24244e-8327-488d-9fcc-290e61220905" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_d5dca1e5-fdb3-4ff0-ac53-64ddb9baf1ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_d5dca1e5-fdb3-4ff0-ac53-64ddb9baf1ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_b02909d7-3616-4dd2-ad55-ab2adcc6f727" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_b02909d7-3616-4dd2-ad55-ab2adcc6f727" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_6204face-68b4-452b-8f61-798ab97c4553" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_6204face-68b4-452b-8f61-798ab97c4553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_af3e9567-69ad-4f50-8256-c482483423ff" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_6fcba0b4-c2f6-4e9d-a368-a62cb91ae870" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_6fcba0b4-c2f6-4e9d-a368-a62cb91ae870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_48b616af-6ca3-41e4-aa3b-a7813f3d5cd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_48b616af-6ca3-41e4-aa3b-a7813f3d5cd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_015fbd3f-9a42-44cf-a0bb-27f8a12fb4ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_015fbd3f-9a42-44cf-a0bb-27f8a12fb4ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_32ca2a03-043a-4cbd-9234-d0573062ab47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_5817b26b-d02c-4395-9ae8-e7d7c76f7bc6" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_32ca2a03-043a-4cbd-9234-d0573062ab47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9e1db0b1-4974-4ff8-8c2f-3b907bc53368" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_41ba4cf8-e577-4e8a-8f4f-e10c3e733c7c" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_9e1db0b1-4974-4ff8-8c2f-3b907bc53368" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_f38c6d7f-97dc-48e1-91c2-dcecf046d2af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_f38c6d7f-97dc-48e1-91c2-dcecf046d2af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_59bed816-737d-4315-8549-84f94f2b7c34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_59bed816-737d-4315-8549-84f94f2b7c34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_882b9cab-e63d-47b8-8934-dc2c05c6ce11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_882b9cab-e63d-47b8-8934-dc2c05c6ce11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_02c50eb1-87b2-4df9-92a6-82bbb8128399" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_34b24f42-544b-47d1-9e6c-21aef0eea44e" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_02c50eb1-87b2-4df9-92a6-82bbb8128399" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_68993c63-05f2-45ee-832a-0ebcd793d75a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_68993c63-05f2-45ee-832a-0ebcd793d75a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_caeab0ca-384f-4908-b7fa-00dca4043bfa" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltyAndMilestonePayments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:to="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_caeab0ca-384f-4908-b7fa-00dca4043bfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_5320d00f-ffcb-4041-a3b2-92f49768b280" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_5320d00f-ffcb-4041-a3b2-92f49768b280" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_18f59e38-4b7a-4470-b630-7053f9f0d969" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_27726dba-cb67-4434-91cc-cbc258e38b28" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_18f59e38-4b7a-4470-b630-7053f9f0d969" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_109d41f2-02e2-40a1-a58b-9b86bd4597a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_109d41f2-02e2-40a1-a58b-9b86bd4597a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_8610cdab-0899-440d-b5c1-0018c2b85eb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_8610cdab-0899-440d-b5c1-0018c2b85eb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_fa33448f-f4fb-4720-9e63-e8201a3abb78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_fa33448f-f4fb-4720-9e63-e8201a3abb78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_3fbf8108-7282-42e4-9c31-ac37ec804a14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_8038010b-a59f-4e1e-b8ba-35c5fc9cd01d" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_3fbf8108-7282-42e4-9c31-ac37ec804a14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_3fbf8108-7282-42e4-9c31-ac37ec804a14" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesIssuanceCostsIncurredButNotYetPaid_4c5cc97f-2a60-4ce9-bd40-5e99dbf3d6ad" xlink:href="anab-20220630.xsd#anab_NoncashAdvanceFutureRoyaltiesIssuanceCostsIncurredButNotYetPaid"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesIssuanceCostsIncurredButNotYetPaid_4c5cc97f-2a60-4ce9-bd40-5e99dbf3d6ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_d9daba1a-9c22-491b-996d-b71d17a862e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:to="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_d9daba1a-9c22-491b-996d-b71d17a862e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_bcb0fa2d-4452-4429-85e3-07f5bc046e1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_bcb0fa2d-4452-4429-85e3-07f5bc046e1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ReceivablesForStockOptionsExercised_8175f495-daaa-48e4-9138-49574222c893" xlink:href="anab-20220630.xsd#anab_ReceivablesForStockOptionsExercised"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_e0ad013d-6871-4844-9d86-c5b47d756e3d" xlink:to="loc_anab_ReceivablesForStockOptionsExercised_8175f495-daaa-48e4-9138-49574222c893" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/DescriptionoftheBusiness" xlink:type="simple" xlink:href="anab-20220630.xsd#DescriptionoftheBusiness"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/DescriptionoftheBusiness" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_793304e9-773a-43fe-bc26-35a5dcb2b192" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NatureOfOperations_50f2f189-020e-41b9-a078-44b134f4c64c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NatureOfOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_793304e9-773a-43fe-bc26-35a5dcb2b192" xlink:to="loc_us-gaap_NatureOfOperations_50f2f189-020e-41b9-a078-44b134f4c64c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="anab-20220630.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_7e816eef-8a8a-4c42-ab38-a142b4bae895" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_50f52a97-ac8c-48cc-b74f-d46e0c90add0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7e816eef-8a8a-4c42-ab38-a142b4bae895" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_50f52a97-ac8c-48cc-b74f-d46e0c90add0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="anab-20220630.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_7f3d5f20-0580-449c-bced-724c7a4f6e7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_fb0e3cad-4a95-4705-ab0d-ec77bb5c93f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7f3d5f20-0580-449c-bced-724c7a4f6e7c" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_fb0e3cad-4a95-4705-ab0d-ec77bb5c93f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_f3865980-4e1b-4aa6-aeba-b63f59debb06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConsolidationPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7f3d5f20-0580-449c-bced-724c7a4f6e7c" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_f3865980-4e1b-4aa6-aeba-b63f59debb06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_14668b6a-deb2-4aab-83b9-3a0916a924e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7f3d5f20-0580-449c-bced-724c7a4f6e7c" xlink:to="loc_us-gaap_UseOfEstimates_14668b6a-deb2-4aab-83b9-3a0916a924e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_ef41d1fd-43c9-497c-be17-cfe7d0e7d9fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_7f3d5f20-0580-449c-bced-724c7a4f6e7c" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_ef41d1fd-43c9-497c-be17-cfe7d0e7d9fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="anab-20220630.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_0c1f443b-38be-45b9-8d75-5fc70f3e32f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_577cd65e-ef09-4de3-849a-7ecad2d9e10f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_0c1f443b-38be-45b9-8d75-5fc70f3e32f8" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_577cd65e-ef09-4de3-849a-7ecad2d9e10f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#SummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_ebe67a31-6802-4b56-a9cb-ab59cc6518f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_115c8120-3fd5-4b51-8d95-4f9a8bed5cb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ebe67a31-6802-4b56-a9cb-ab59cc6518f2" xlink:to="loc_us-gaap_NumberOfReportableSegments_115c8120-3fd5-4b51-8d95-4f9a8bed5cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesSummaryofPotentiallyDilutiveSecuritiesDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#SummaryofSignificantAccountingPoliciesSummaryofPotentiallyDilutiveSecuritiesDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SummaryofSignificantAccountingPoliciesSummaryofPotentiallyDilutiveSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_69ec8d1a-2adc-4a2d-b9ba-4dbf117ad492" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_0611861b-ab8f-4ba7-8a8c-d278ad2bfbe2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_69ec8d1a-2adc-4a2d-b9ba-4dbf117ad492" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_0611861b-ab8f-4ba7-8a8c-d278ad2bfbe2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_c8aaa049-478f-49e5-9dd2-8d5abf415775" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_0611861b-ab8f-4ba7-8a8c-d278ad2bfbe2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_c8aaa049-478f-49e5-9dd2-8d5abf415775" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e297914-f46f-41b9-b1d7-f1c0a8274f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_c8aaa049-478f-49e5-9dd2-8d5abf415775" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e297914-f46f-41b9-b1d7-f1c0a8274f5f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_3be7817c-64a6-4de0-b2e0-88d56ed415fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e297914-f46f-41b9-b1d7-f1c0a8274f5f" xlink:to="loc_us-gaap_EmployeeStockOptionMember_3be7817c-64a6-4de0-b2e0-88d56ed415fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_4bec5c4e-9eba-4fab-8982-d70777e62ec2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_0611861b-ab8f-4ba7-8a8c-d278ad2bfbe2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_4bec5c4e-9eba-4fab-8982-d70777e62ec2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_44c42038-9179-4d1a-a0c6-6034f58c4956" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_4bec5c4e-9eba-4fab-8982-d70777e62ec2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_44c42038-9179-4d1a-a0c6-6034f58c4956" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosures" xlink:type="simple" xlink:href="anab-20220630.xsd#BalanceSheetAccountsandSupplementalDisclosures"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosures" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_fb06ee5a-5a1b-42a1-b4db-886f9465f0e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_3d24fb48-70e1-43bb-99e3-8bfce69da4fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_fb06ee5a-5a1b-42a1-b4db-886f9465f0e8" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_3d24fb48-70e1-43bb-99e3-8bfce69da4fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresTables" xlink:type="simple" xlink:href="anab-20220630.xsd#BalanceSheetAccountsandSupplementalDisclosuresTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_00f4270d-5a2d-4574-a33d-168a795acd13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_a7f74439-b5f1-4234-8f2d-49df4932f5c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_00f4270d-5a2d-4574-a33d-168a795acd13" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_a7f74439-b5f1-4234-8f2d-49df4932f5c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_4804bcfd-5ac9-4b64-b247-99c27749fa16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_00f4270d-5a2d-4574-a33d-168a795acd13" xlink:to="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_4804bcfd-5ac9-4b64-b247-99c27749fa16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentnetDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentnetDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresPropertyandEquipmentnetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_049929b9-05c8-43fa-bd5d-6927156d97a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_7e061471-2eeb-4647-97ce-d7fd4889ce9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_049929b9-05c8-43fa-bd5d-6927156d97a7" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_7e061471-2eeb-4647-97ce-d7fd4889ce9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0a05f50f-a82f-4cb6-9dfe-4e2b39929fbd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_7e061471-2eeb-4647-97ce-d7fd4889ce9c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0a05f50f-a82f-4cb6-9dfe-4e2b39929fbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_fceb870a-31d6-4822-8dec-425fadf64cf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_0a05f50f-a82f-4cb6-9dfe-4e2b39929fbd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_fceb870a-31d6-4822-8dec-425fadf64cf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LaboratoryEquipmentMember_cbfc3653-0d82-48a2-b7c0-a68ea22e0856" xlink:href="anab-20220630.xsd#anab_LaboratoryEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_fceb870a-31d6-4822-8dec-425fadf64cf4" xlink:to="loc_anab_LaboratoryEquipmentMember_cbfc3653-0d82-48a2-b7c0-a68ea22e0856" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_637ab7f7-2398-4f7e-88fd-f5ea4047f157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_fceb870a-31d6-4822-8dec-425fadf64cf4" xlink:to="loc_us-gaap_OfficeEquipmentMember_637ab7f7-2398-4f7e-88fd-f5ea4047f157" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_0c7e4bcf-7568-441d-8701-1d130962aa73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_fceb870a-31d6-4822-8dec-425fadf64cf4" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_0c7e4bcf-7568-441d-8701-1d130962aa73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cecdec57-fc57-4f1b-a0ca-8970518be923" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_7e061471-2eeb-4647-97ce-d7fd4889ce9c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cecdec57-fc57-4f1b-a0ca-8970518be923" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_bdf260f9-499c-4069-af5d-17c38bb4c76f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cecdec57-fc57-4f1b-a0ca-8970518be923" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_bdf260f9-499c-4069-af5d-17c38bb4c76f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_aa585f15-e272-4d6a-aae8-ff2aecb6e102" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cecdec57-fc57-4f1b-a0ca-8970518be923" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_aa585f15-e272-4d6a-aae8-ff2aecb6e102" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_806dccf0-454b-4eff-9029-a6c0770bfd46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cecdec57-fc57-4f1b-a0ca-8970518be923" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_806dccf0-454b-4eff-9029-a6c0770bfd46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/BalanceSheetAccountsandSupplementalDisclosuresAccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetRelatedDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_76978116-fd2b-4bc4-a3aa-0cee33bdcbad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_76978116-fd2b-4bc4-a3aa-0cee33bdcbad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_88f9aa1c-a77c-47c5-bccf-08001773f258" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_88f9aa1c-a77c-47c5-bccf-08001773f258" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AccruedResearchAndDevelopmentExpensesCurrent_9d5e87af-2b17-45b8-af97-e0513ef3bcc4" xlink:href="anab-20220630.xsd#anab_AccruedResearchAndDevelopmentExpensesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:to="loc_anab_AccruedResearchAndDevelopmentExpensesCurrent_9d5e87af-2b17-45b8-af97-e0513ef3bcc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_16cef341-7169-4db9-b515-510e5ff72f48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_16cef341-7169-4db9-b515-510e5ff72f48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_a213ab33-7dac-4913-880d-db503719f24e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetRelatedDisclosuresAbstract_6148dbee-d6bd-46ed-83fe-bcc5c201eaf3" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_a213ab33-7dac-4913-880d-db503719f24e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreements" xlink:type="simple" xlink:href="anab-20220630.xsd#CollaborativeResearchandDevelopmentAgreements"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_455a4aa8-9513-49f0-89ac-b89265e8345d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_c4a636a5-bcac-4d42-b603-5d92bcf3612a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_455a4aa8-9513-49f0-89ac-b89265e8345d" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_c4a636a5-bcac-4d42-b603-5d92bcf3612a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsTables" xlink:type="simple" xlink:href="anab-20220630.xsd#CollaborativeResearchandDevelopmentAgreementsTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_29fac468-3191-4893-9463-1173938e7674" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_0ef0d46f-685f-4295-ab2d-705dc195afda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_29fac468-3191-4893-9463-1173938e7674" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTableTextBlock_0ef0d46f-685f-4295-ab2d-705dc195afda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsNarrativeDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CollaborativeResearchandDevelopmentAgreementsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_55910419-8ec6-4b4b-9400-8aec54308b06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_55910419-8ec6-4b4b-9400-8aec54308b06" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_8c93e59d-fe96-4b28-b062-3d7947716ba7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:to="loc_srt_CounterpartyNameAxis_8c93e59d-fe96-4b28-b062-3d7947716ba7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_557da0ce-37e5-4dfa-b1f7-3359f2486c7e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_8c93e59d-fe96-4b28-b062-3d7947716ba7" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_557da0ce-37e5-4dfa-b1f7-3359f2486c7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_GlaxoSmithKlineMember_a2f7805b-a0dc-4f73-a23a-7581e11a3156" xlink:href="anab-20220630.xsd#anab_GlaxoSmithKlineMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_557da0ce-37e5-4dfa-b1f7-3359f2486c7e" xlink:to="loc_anab_GlaxoSmithKlineMember_a2f7805b-a0dc-4f73-a23a-7581e11a3156" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_BristolMyersSquibbMember_c651b24d-fe8a-4b60-a604-6fc1ad272242" xlink:href="anab-20220630.xsd#anab_BristolMyersSquibbMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_557da0ce-37e5-4dfa-b1f7-3359f2486c7e" xlink:to="loc_anab_BristolMyersSquibbMember_c651b24d-fe8a-4b60-a604-6fc1ad272242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_68d2a918-a7cc-42b5-8165-14130ee3fe77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:to="loc_us-gaap_TypeOfArrangementAxis_68d2a918-a7cc-42b5-8165-14130ee3fe77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_fdc40515-bdb0-49cb-9abf-e50153dead34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_68d2a918-a7cc-42b5-8165-14130ee3fe77" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_fdc40515-bdb0-49cb-9abf-e50153dead34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementMember_27c6fd06-1ae8-4c72-acfb-c05c80c5223b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_fdc40515-bdb0-49cb-9abf-e50153dead34" xlink:to="loc_us-gaap_CollaborativeArrangementMember_27c6fd06-1ae8-4c72-acfb-c05c80c5223b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:href="anab-20220630.xsd#anab_RoyaltyAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementMember_27c6fd06-1ae8-4c72-acfb-c05c80c5223b" xlink:to="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RoyaltyAgreementUpTo10BillionMember_d91cb771-13d0-4acb-8cca-970990e27ba1" xlink:href="anab-20220630.xsd#anab_RoyaltyAgreementUpTo10BillionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:to="loc_anab_RoyaltyAgreementUpTo10BillionMember_d91cb771-13d0-4acb-8cca-970990e27ba1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RoyaltyAgreementAbove10BillionMember_c021bbdd-5982-4169-80f8-d9f384f356b2" xlink:href="anab-20220630.xsd#anab_RoyaltyAgreementAbove10BillionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:to="loc_anab_RoyaltyAgreementAbove10BillionMember_c021bbdd-5982-4169-80f8-d9f384f356b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CollaborationAndExclusiveLicenseAgreementMember_49ca3dec-080b-46dc-bd9c-7499d6a9e40c" xlink:href="anab-20220630.xsd#anab_CollaborationAndExclusiveLicenseAgreementMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:to="loc_anab_CollaborationAndExclusiveLicenseAgreementMember_49ca3dec-080b-46dc-bd9c-7499d6a9e40c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RoyaltyPurchaseAgreementMember_48963ce7-13a0-4e55-930c-4ac4a05ffd7a" xlink:href="anab-20220630.xsd#anab_RoyaltyPurchaseAgreementMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_RoyaltyAgreementMember_ba411956-9024-4377-a939-bb11b2632735" xlink:to="loc_anab_RoyaltyPurchaseAgreementMember_48963ce7-13a0-4e55-930c-4ac4a05ffd7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_988749d2-8966-4db2-845c-78a795c0e190" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:to="loc_srt_RangeAxis_988749d2-8966-4db2-845c-78a795c0e190" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_dbc5ab75-5491-4382-ad8a-e8ef59a4e6e3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_988749d2-8966-4db2-845c-78a795c0e190" xlink:to="loc_srt_RangeMember_dbc5ab75-5491-4382-ad8a-e8ef59a4e6e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_40e82801-ed51-43db-9387-51cad64a9c09" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_dbc5ab75-5491-4382-ad8a-e8ef59a4e6e3" xlink:to="loc_srt_MinimumMember_40e82801-ed51-43db-9387-51cad64a9c09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_7a4f121f-ca92-4b8d-8140-82573fc45729" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_dbc5ab75-5491-4382-ad8a-e8ef59a4e6e3" xlink:to="loc_srt_MaximumMember_7a4f121f-ca92-4b8d-8140-82573fc45729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_59821dc9-11b4-4c10-befe-f6492853fd78" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:to="loc_srt_ProductOrServiceAxis_59821dc9-11b4-4c10-befe-f6492853fd78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_59821dc9-11b4-4c10-befe-f6492853fd78" xlink:to="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_980fcc8e-a641-412c-a100-d9ffac05ea39" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:to="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_980fcc8e-a641-412c-a100-d9ffac05ea39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ZejulaMember_c57a26de-578e-453b-9e6d-c0a2f93fa3b0" xlink:href="anab-20220630.xsd#anab_ZejulaMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:to="loc_anab_ZejulaMember_c57a26de-578e-453b-9e6d-c0a2f93fa3b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiPD1AntagonistAntibodyCC90006Member_51056c1d-a3e1-44f2-b5ad-aa8f84863104" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiPD1AntagonistAntibodyCC90006Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:to="loc_anab_AnaptysBioGeneratedAntiPD1AntagonistAntibodyCC90006Member_51056c1d-a3e1-44f2-b5ad-aa8f84863104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ZejulaAndAnaptysBioGeneratedJEMPERLIMember_86624794-1c79-4444-9774-544a2af25063" xlink:href="anab-20220630.xsd#anab_ZejulaAndAnaptysBioGeneratedJEMPERLIMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_11c85ce7-4924-4f60-b1a8-5947b8e8b2e5" xlink:to="loc_anab_ZejulaAndAnaptysBioGeneratedJEMPERLIMember_86624794-1c79-4444-9774-544a2af25063" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_a93b4daf-e75d-4c49-955b-d4f2717df476" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMultipledeliverableArrangementsUpfrontFeeReceived_5b3cf1a6-de0e-4e01-9cb0-67390987e3ad" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMultipledeliverableArrangementsUpfrontFeeReceived"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMultipledeliverableArrangementsUpfrontFeeReceived_5b3cf1a6-de0e-4e01-9cb0-67390987e3ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodNumberOfOutstandingResearchAndDevelopmentTargets_b6f39f52-0f71-4270-a668-327870136abb" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodNumberOfOutstandingResearchAndDevelopmentTargets"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodNumberOfOutstandingResearchAndDevelopmentTargets_b6f39f52-0f71-4270-a668-327870136abb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents_040ff548-280e-4250-a5d5-d0167a31175b" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents_040ff548-280e-4250-a5d5-d0167a31175b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodContingentUponCertainUnitedStatesAndEuropeanRegulatorySubmissionsAndApprovals_6adbdeb1-db5d-420f-a6b6-2b47ed6f11a8" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodContingentUponCertainUnitedStatesAndEuropeanRegulatorySubmissionsAndApprovals"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodContingentUponCertainUnitedStatesAndEuropeanRegulatorySubmissionsAndApprovals_6adbdeb1-db5d-420f-a6b6-2b47ed6f11a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodContingentUponAchievementOfSpecifiedLevelsOfWorldwideSales_bec5f669-d7ee-4dbe-a2b2-40db4023e591" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodContingentUponAchievementOfSpecifiedLevelsOfWorldwideSales"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodContingentUponAchievementOfSpecifiedLevelsOfWorldwideSales_bec5f669-d7ee-4dbe-a2b2-40db4023e591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NetSalesRoyaltyPercent_dd4fe61a-8ce8-470d-9269-3a7d3d5a5f03" xlink:href="anab-20220630.xsd#anab_NetSalesRoyaltyPercent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_NetSalesRoyaltyPercent_dd4fe61a-8ce8-470d-9269-3a7d3d5a5f03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodAgreementTermFollowingFirstCommercialSaleOrExpirationOfTheLastToExpirePatent_5ee295be-d2d3-4552-b0cf-47608fd47b94" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodAgreementTermFollowingFirstCommercialSaleOrExpirationOfTheLastToExpirePatent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodAgreementTermFollowingFirstCommercialSaleOrExpirationOfTheLastToExpirePatent_5ee295be-d2d3-4552-b0cf-47608fd47b94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NetSalesRoyaltyThreshold_c9347dcb-4679-462c-8771-59c59c000926" xlink:href="anab-20220630.xsd#anab_NetSalesRoyaltyThreshold"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_NetSalesRoyaltyThreshold_c9347dcb-4679-462c-8771-59c59c000926" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMultipleDeliverableArrangementsUpfrontFees_364bdfa3-99c3-4a32-9b90-2bc359f4d779" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMultipleDeliverableArrangementsUpfrontFees"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMultipleDeliverableArrangementsUpfrontFees_364bdfa3-99c3-4a32-9b90-2bc359f4d779" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodMilestonesAchievedDuringAmount_91bb8175-481a-4b19-b720-6740b460d2c6" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodMilestonesAchievedDuringAmount"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodMilestonesAchievedDuringAmount_91bb8175-481a-4b19-b720-6740b460d2c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8ddfb190-e7cb-4c68-afd2-c6654098a98c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8ddfb190-e7cb-4c68-afd2-c6654098a98c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesRevenue_924bc9d0-66b2-4462-8a8f-c8f3d288f166" xlink:href="anab-20220630.xsd#anab_NoncashAdvanceFutureRoyaltiesRevenue"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesRevenue_924bc9d0-66b2-4462-8a8f-c8f3d288f166" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodNumberOfMilestonesAchievedDuringPeriod_bc5dea20-e89b-4cac-a910-8103e156dd34" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodNumberOfMilestonesAchievedDuringPeriod"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodNumberOfMilestonesAchievedDuringPeriod_bc5dea20-e89b-4cac-a910-8103e156dd34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodMaximumRevenuePerMilestone_32a84311-3531-46af-9952-cb65992d840b" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodMaximumRevenuePerMilestone"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_498c4e26-1861-4228-9d4e-67264e5aaec2" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodMaximumRevenuePerMilestone_32a84311-3531-46af-9952-cb65992d840b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsScheduleofMilestoneAchievedDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CollaborativeResearchandDevelopmentAgreementsScheduleofMilestoneAchievedDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsScheduleofMilestoneAchievedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_0367f59b-8b00-4b25-a755-8d8c33bb88d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_0367f59b-8b00-4b25-a755-8d8c33bb88d1" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_4dc4b714-52f8-4281-87a3-f7cc8e5cf877" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:to="loc_srt_CounterpartyNameAxis_4dc4b714-52f8-4281-87a3-f7cc8e5cf877" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_cff53e51-2877-41bd-b86a-7636e0e37599" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_4dc4b714-52f8-4281-87a3-f7cc8e5cf877" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_cff53e51-2877-41bd-b86a-7636e0e37599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_GlaxoSmithKlineMember_03772bf2-7288-4d30-b611-9ba40a114009" xlink:href="anab-20220630.xsd#anab_GlaxoSmithKlineMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_cff53e51-2877-41bd-b86a-7636e0e37599" xlink:to="loc_anab_GlaxoSmithKlineMember_03772bf2-7288-4d30-b611-9ba40a114009" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_c17815b2-cbc3-4283-98a7-0059d822f41d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:to="loc_srt_ProductOrServiceAxis_c17815b2-cbc3-4283-98a7-0059d822f41d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e7111940-e23a-4d7b-bf6a-38028a21a689" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_c17815b2-cbc3-4283-98a7-0059d822f41d" xlink:to="loc_srt_ProductsAndServicesDomain_e7111940-e23a-4d7b-bf6a-38028a21a689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_9340e2a7-c23a-415a-8198-6d10996121ca" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_e7111940-e23a-4d7b-bf6a-38028a21a689" xlink:to="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_9340e2a7-c23a-415a-8198-6d10996121ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember_f6490e76-0fc3-4360-8a08-3cff6ef58cc5" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_e7111940-e23a-4d7b-bf6a-38028a21a689" xlink:to="loc_anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember_f6490e76-0fc3-4360-8a08-3cff6ef58cc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member_2c013e08-d4b3-45ec-b852-f6958358efa4" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_e7111940-e23a-4d7b-bf6a-38028a21a689" xlink:to="loc_anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member_2c013e08-d4b3-45ec-b852-f6958358efa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_6af1888d-774a-43d8-a78c-9ad267427aab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:to="loc_us-gaap_TypeOfArrangementAxis_6af1888d-774a-43d8-a78c-9ad267427aab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6af1888d-774a-43d8-a78c-9ad267427aab" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_InVivoToxicologyStudiesMember_c07ff02b-248a-4389-8019-aa32e2239487" xlink:href="anab-20220630.xsd#anab_InVivoToxicologyStudiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_InVivoToxicologyStudiesMember_c07ff02b-248a-4389-8019-aa32e2239487" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ClearanceOfInvestigationalNewDrugFromFDAMember_c6bc6e5b-a440-426c-af56-04a5f9ed2d6f" xlink:href="anab-20220630.xsd#anab_ClearanceOfInvestigationalNewDrugFromFDAMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_ClearanceOfInvestigationalNewDrugFromFDAMember_c6bc6e5b-a440-426c-af56-04a5f9ed2d6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_Phase2ClinicalTrialInitiationMember_c6a2edce-4191-4577-bb4b-dfe3f66db3fd" xlink:href="anab-20220630.xsd#anab_Phase2ClinicalTrialInitiationMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_Phase2ClinicalTrialInitiationMember_c6a2edce-4191-4577-bb4b-dfe3f66db3fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_Phase3ClinicalTrialInitiationFirstIndicationMember_662c1b19-bd8c-46f8-b8fe-9341d447d8a9" xlink:href="anab-20220630.xsd#anab_Phase3ClinicalTrialInitiationFirstIndicationMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_Phase3ClinicalTrialInitiationFirstIndicationMember_662c1b19-bd8c-46f8-b8fe-9341d447d8a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_Phase3ClinicalTrialInitiationSecondIndicationMember_0965850f-6333-4a39-8ee1-d1bbab4ee2cb" xlink:href="anab-20220630.xsd#anab_Phase3ClinicalTrialInitiationSecondIndicationMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_Phase3ClinicalTrialInitiationSecondIndicationMember_0965850f-6333-4a39-8ee1-d1bbab4ee2cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FilingOfBiologicsLicenseApplicationFirstIndicationMember_0ea865d7-44cc-4fc5-b2f3-d2c3484dba34" xlink:href="anab-20220630.xsd#anab_FilingOfBiologicsLicenseApplicationFirstIndicationMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FilingOfBiologicsLicenseApplicationFirstIndicationMember_0ea865d7-44cc-4fc5-b2f3-d2c3484dba34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FilingOfMMAFirstIndicationMember_8ecf3d79-bb22-4c56-b5f3-bbefed7c6540" xlink:href="anab-20220630.xsd#anab_FilingOfMMAFirstIndicationMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FilingOfMMAFirstIndicationMember_8ecf3d79-bb22-4c56-b5f3-bbefed7c6540" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FilingOfBiologicsLicenseApplicationSecondIndicationMember_b19685ae-5828-46b4-8879-94d3e90b7370" xlink:href="anab-20220630.xsd#anab_FilingOfBiologicsLicenseApplicationSecondIndicationMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FilingOfBiologicsLicenseApplicationSecondIndicationMember_b19685ae-5828-46b4-8879-94d3e90b7370" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FirstBiologicsLicenseApplicationApprovalDMMRECMember_cd17e3f2-bb27-4b8f-ab12-ef2e7b404698" xlink:href="anab-20220630.xsd#anab_FirstBiologicsLicenseApplicationApprovalDMMRECMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FirstBiologicsLicenseApplicationApprovalDMMRECMember_cd17e3f2-bb27-4b8f-ab12-ef2e7b404698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FirstMarketingAuthorizationApplicationApprovalFirstIndicationMember_fb697058-079c-4e40-aa58-37c17b18b032" xlink:href="anab-20220630.xsd#anab_FirstMarketingAuthorizationApplicationApprovalFirstIndicationMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FirstMarketingAuthorizationApplicationApprovalFirstIndicationMember_fb697058-079c-4e40-aa58-37c17b18b032" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FirstBiologicsLicenseApplicationApprovalSecondIndicationMember_d09c93f6-fce8-45a2-a9ba-b6b933429ad2" xlink:href="anab-20220630.xsd#anab_FirstBiologicsLicenseApplicationApprovalSecondIndicationMember"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1f39ea75-3ca6-42b6-85af-84eca70c77e2" xlink:to="loc_anab_FirstBiologicsLicenseApplicationApprovalSecondIndicationMember_d09c93f6-fce8-45a2-a9ba-b6b933429ad2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_9fc9c50f-61f9-4c0b-8daa-c7e9ab21a5a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_f91a42e1-b901-4db0-8ad3-3cfd82d9801e" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_9fc9c50f-61f9-4c0b-8daa-c7e9ab21a5a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_36ee53b3-edb3-4a7d-aae3-60d277d97477" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_9fc9c50f-61f9-4c0b-8daa-c7e9ab21a5a8" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_36ee53b3-edb3-4a7d-aae3-60d277d97477" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsScheduleofFutureRevenueNotYetRecognizedDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CollaborativeResearchandDevelopmentAgreementsScheduleofFutureRevenueNotYetRecognizedDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CollaborativeResearchandDevelopmentAgreementsScheduleofFutureRevenueNotYetRecognizedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_e9987d7a-fb85-40ce-80e3-6ee8e98bed78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_e9987d7a-fb85-40ce-80e3-6ee8e98bed78" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_75fa279f-dde4-45d6-a223-b8b1d8e31337" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:to="loc_srt_CounterpartyNameAxis_75fa279f-dde4-45d6-a223-b8b1d8e31337" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e6d1c7d1-2609-4df2-85ed-63d42b2f7ab2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_75fa279f-dde4-45d6-a223-b8b1d8e31337" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e6d1c7d1-2609-4df2-85ed-63d42b2f7ab2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_GlaxoSmithKlineMember_b8d74918-1194-46b1-88c8-60fa1f577ef6" xlink:href="anab-20220630.xsd#anab_GlaxoSmithKlineMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_e6d1c7d1-2609-4df2-85ed-63d42b2f7ab2" xlink:to="loc_anab_GlaxoSmithKlineMember_b8d74918-1194-46b1-88c8-60fa1f577ef6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_d0c454c8-350e-4427-9d4a-7d11ce51405a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:to="loc_srt_ProductOrServiceAxis_d0c454c8-350e-4427-9d4a-7d11ce51405a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_886827fd-db4d-45c8-a51e-49d860e4b9fc" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_d0c454c8-350e-4427-9d4a-7d11ce51405a" xlink:to="loc_srt_ProductsAndServicesDomain_886827fd-db4d-45c8-a51e-49d860e4b9fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_8074181e-424a-4536-9293-d3edcfc5f391" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_886827fd-db4d-45c8-a51e-49d860e4b9fc" xlink:to="loc_anab_AnaptysBioGeneratedAntiPD1JEMPERLIDostarlimabMember_8074181e-424a-4536-9293-d3edcfc5f391" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember_dd768724-e89a-42e9-ad5a-0d5a98782105" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_886827fd-db4d-45c8-a51e-49d860e4b9fc" xlink:to="loc_anab_AnaptysBioGeneratedAntiTIM3GSK4069889ACobolimabMember_dd768724-e89a-42e9-ad5a-0d5a98782105" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member_89eb9fcd-ed3e-4c09-b6da-3bd807aee286" xlink:href="anab-20220630.xsd#anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_886827fd-db4d-45c8-a51e-49d860e4b9fc" xlink:to="loc_anab_AnaptysBioGeneratedAntiLAG3GSK40974386Member_89eb9fcd-ed3e-4c09-b6da-3bd807aee286" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_f4e8a055-3b56-4f8b-a625-22d525c6ea98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:to="loc_us-gaap_TypeOfArrangementAxis_f4e8a055-3b56-4f8b-a625-22d525c6ea98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_dd7fecda-46d2-4f1e-8d11-c6e9632a7dc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_f4e8a055-3b56-4f8b-a625-22d525c6ea98" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_dd7fecda-46d2-4f1e-8d11-c6e9632a7dc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_PreClinicalAndDevelopmentMember_14dbb3a7-a66d-43ef-9ac2-a10784315282" xlink:href="anab-20220630.xsd#anab_PreClinicalAndDevelopmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_dd7fecda-46d2-4f1e-8d11-c6e9632a7dc7" xlink:to="loc_anab_PreClinicalAndDevelopmentMember_14dbb3a7-a66d-43ef-9ac2-a10784315282" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RegulatoryMember_ab755765-4aa4-4ff5-9b9a-a247000b32f9" xlink:href="anab-20220630.xsd#anab_RegulatoryMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_dd7fecda-46d2-4f1e-8d11-c6e9632a7dc7" xlink:to="loc_anab_RegulatoryMember_ab755765-4aa4-4ff5-9b9a-a247000b32f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommercialMember_3e1b983d-a4af-4b7b-ad7f-107eb38ae508" xlink:href="anab-20220630.xsd#anab_CommercialMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_dd7fecda-46d2-4f1e-8d11-c6e9632a7dc7" xlink:to="loc_anab_CommercialMember_3e1b983d-a4af-4b7b-ad7f-107eb38ae508" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_fab28f24-08c0-4fe2-a881-c55eec750383" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_22ade0ac-bdac-433e-9c1d-863e03486ebf" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_fab28f24-08c0-4fe2-a881-c55eec750383" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents_339c6bf3-8e77-437e-8dbc-71bcccaceec0" xlink:href="anab-20220630.xsd#anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_fab28f24-08c0-4fe2-a881-c55eec750383" xlink:to="loc_anab_RevenueRecognitionMilestoneMethodContingentUponPreClinicalRegulatoryAndCommercialEvents_339c6bf3-8e77-437e-8dbc-71bcccaceec0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SaleofFutureRoyalties" xlink:type="simple" xlink:href="anab-20220630.xsd#SaleofFutureRoyalties"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SaleofFutureRoyalties" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_ab59cef1-1f50-4008-a8cb-076536645acd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_SaleOfFutureRoyaltiesTextBlockTextBlock_1fc967e5-7164-46f8-a298-b2613e6ec05f" xlink:href="anab-20220630.xsd#anab_SaleOfFutureRoyaltiesTextBlockTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_ab59cef1-1f50-4008-a8cb-076536645acd" xlink:to="loc_anab_SaleOfFutureRoyaltiesTextBlockTextBlock_1fc967e5-7164-46f8-a298-b2613e6ec05f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesTables" xlink:type="simple" xlink:href="anab-20220630.xsd#SaleofFutureRoyaltiesTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_e94cc4f7-e632-4cc7-bf4a-77e109eed707" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_f28ed284-0a2f-4f31-bb0a-6e806f3c1d49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_e94cc4f7-e632-4cc7-bf4a-77e109eed707" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_f28ed284-0a2f-4f31-bb0a-6e806f3c1d49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesNarrativesDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#SaleofFutureRoyaltiesNarrativesDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesNarrativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_c4aff35f-a830-4262-80d5-479be0151953" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:href="anab-20220630.xsd#anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_c4aff35f-a830-4262-80d5-479be0151953" xlink:to="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_c6e65883-5f4e-43dd-94db-4d0b1519e604" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:to="loc_us-gaap_TypeOfArrangementAxis_c6e65883-5f4e-43dd-94db-4d0b1519e604" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1e77de70-07d9-4972-b4c4-6efa8763cd39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_c6e65883-5f4e-43dd-94db-4d0b1519e604" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1e77de70-07d9-4972-b4c4-6efa8763cd39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RoyaltyPurchaseAgreementMember_ed8e4098-47e4-4aa0-a2ff-09544a07d528" xlink:href="anab-20220630.xsd#anab_RoyaltyPurchaseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_1e77de70-07d9-4972-b4c4-6efa8763cd39" xlink:to="loc_anab_RoyaltyPurchaseAgreementMember_ed8e4098-47e4-4aa0-a2ff-09544a07d528" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_408be8d9-1715-497a-9a71-02cc200b11b4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:to="loc_srt_CounterpartyNameAxis_408be8d9-1715-497a-9a71-02cc200b11b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32aa6f81-98d4-488e-89c4-c7e34dfba57b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_408be8d9-1715-497a-9a71-02cc200b11b4" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32aa6f81-98d4-488e-89c4-c7e34dfba57b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_SagardHealthcareRoyaltyPartnersLPMember_bcd47eed-bb68-4904-8d19-3c0af5e8f625" xlink:href="anab-20220630.xsd#anab_SagardHealthcareRoyaltyPartnersLPMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32aa6f81-98d4-488e-89c4-c7e34dfba57b" xlink:to="loc_anab_SagardHealthcareRoyaltyPartnersLPMember_bcd47eed-bb68-4904-8d19-3c0af5e8f625" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_GlaxoSmithKlineMember_32d73baa-fb62-4d3b-9d59-023c0ed3bd89" xlink:href="anab-20220630.xsd#anab_GlaxoSmithKlineMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32aa6f81-98d4-488e-89c4-c7e34dfba57b" xlink:to="loc_anab_GlaxoSmithKlineMember_32d73baa-fb62-4d3b-9d59-023c0ed3bd89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesPaymentAxis_e85cb26a-75c2-4913-8c36-15aa9c1b2627" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesPaymentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:to="loc_anab_AdvanceFutureRoyaltiesPaymentAxis_e85cb26a-75c2-4913-8c36-15aa9c1b2627" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesPaymentDomain_7a01e8fa-582f-418c-bcaa-dac0b4e4df14" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesPaymentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_AdvanceFutureRoyaltiesPaymentAxis_e85cb26a-75c2-4913-8c36-15aa9c1b2627" xlink:to="loc_anab_AdvanceFutureRoyaltiesPaymentDomain_7a01e8fa-582f-418c-bcaa-dac0b4e4df14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FirstInstallmentMember_ed37a921-ffb4-4aab-956b-42c62b678f64" xlink:href="anab-20220630.xsd#anab_FirstInstallmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_AdvanceFutureRoyaltiesPaymentDomain_7a01e8fa-582f-418c-bcaa-dac0b4e4df14" xlink:to="loc_anab_FirstInstallmentMember_ed37a921-ffb4-4aab-956b-42c62b678f64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_SecondInstallmentMember_720193d5-5135-4790-8a82-bb20ff272f8e" xlink:href="anab-20220630.xsd#anab_SecondInstallmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_AdvanceFutureRoyaltiesPaymentDomain_7a01e8fa-582f-418c-bcaa-dac0b4e4df14" xlink:to="loc_anab_SecondInstallmentMember_720193d5-5135-4790-8a82-bb20ff272f8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ThirdInstallmentMember_4ddfbc3b-f09c-4e73-93c2-64a10f04bc9a" xlink:href="anab-20220630.xsd#anab_ThirdInstallmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_AdvanceFutureRoyaltiesPaymentDomain_7a01e8fa-582f-418c-bcaa-dac0b4e4df14" xlink:to="loc_anab_ThirdInstallmentMember_4ddfbc3b-f09c-4e73-93c2-64a10f04bc9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:href="anab-20220630.xsd#anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesTable_59179df3-49b8-454e-8861-2d155e3ceaa6" xlink:to="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ProceedsFromAdvanceFutureRoyalties_05c66afe-2d55-473e-a5ea-5ec973491d45" xlink:href="anab-20220630.xsd#anab_ProceedsFromAdvanceFutureRoyalties"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_ProceedsFromAdvanceFutureRoyalties_05c66afe-2d55-473e-a5ea-5ec973491d45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesAnnualSalesThreshold_05eb4a42-f934-4b41-b58f-74290d33d8a4" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesAnnualSalesThreshold"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesAnnualSalesThreshold_05eb4a42-f934-4b41-b58f-74290d33d8a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesAggregatePaymentThreshold_7e3f9978-d9c1-49ac-9348-dbafb38c76c8" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesAggregatePaymentThreshold"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesAggregatePaymentThreshold_7e3f9978-d9c1-49ac-9348-dbafb38c76c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesAggregatePaymentThresholdPercent_740964f3-8cdf-4d11-b95e-2e582c674eb2" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesAggregatePaymentThresholdPercent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesAggregatePaymentThresholdPercent_740964f3-8cdf-4d11-b95e-2e582c674eb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_964a7950-ae3a-4070-a14c-bff0c490be1f" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltyAndMilestonePayments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_964a7950-ae3a-4070-a14c-bff0c490be1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesInternalRateOfReturn_970dc98c-c21d-4aa0-af17-3e99ddd04791" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesInternalRateOfReturn"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesInternalRateOfReturn_970dc98c-c21d-4aa0-af17-3e99ddd04791" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_a0b3a82d-d7c8-4d47-ae40-8c6d5fbb66fa" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesLiabilityNoncurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesLiabilityNoncurrent_a0b3a82d-d7c8-4d47-ae40-8c6d5fbb66fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesIssuanceCosts_7072f16b-1076-4629-8fee-f9fa438ed736" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesIssuanceCosts"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesIssuanceCosts_7072f16b-1076-4629-8fee-f9fa438ed736" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesInterestRateEffectivePercentage_6914e244-a0a2-4b1a-b553-20e60ca0019f" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesInterestRateEffectivePercentage"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_AdvanceFutureRoyaltiesInterestRateEffectivePercentage_6914e244-a0a2-4b1a-b553-20e60ca0019f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesRevenue_4bff2c39-16fd-42ac-b7d4-55698e9ef9a1" xlink:href="anab-20220630.xsd#anab_NoncashAdvanceFutureRoyaltiesRevenue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesRevenue_4bff2c39-16fd-42ac-b7d4-55698e9ef9a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashAdvanceFutureRoyaltiesInterestExpense_c23c491f-939b-4eed-805a-8fe0f6067877" xlink:href="anab-20220630.xsd#anab_NoncashAdvanceFutureRoyaltiesInterestExpense"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesLineItems_e5aab5c3-c6a6-44e5-83f0-515b292c1355" xlink:to="loc_anab_NoncashAdvanceFutureRoyaltiesInterestExpense_c23c491f-939b-4eed-805a-8fe0f6067877" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesScheduleofRoyaltyTransactionActivityDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#SaleofFutureRoyaltiesScheduleofRoyaltyTransactionActivityDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/SaleofFutureRoyaltiesScheduleofRoyaltyTransactionActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_73c078fa-4112-4e8f-9165-ad10c3e2a664" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:href="anab-20220630.xsd#anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherLiabilitiesDisclosureAbstract_73c078fa-4112-4e8f-9165-ad10c3e2a664" xlink:to="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesLiabilities_c95d0a64-bfae-468d-833f-81e2679484f7" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesLiabilities"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_AdvanceFutureRoyaltiesLiabilities_c95d0a64-bfae-468d-833f-81e2679484f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesIssuanceCosts_632ba5c5-4a0d-417f-94b5-0f76b3c4f073" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesIssuanceCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_AdvanceFutureRoyaltiesIssuanceCosts_632ba5c5-4a0d-417f-94b5-0f76b3c4f073" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AmortizationOfAdvanceFutureRoyaltiesIssuanceCosts_0e732e1b-e2a6-49c3-8083-c3fd8ff5019d" xlink:href="anab-20220630.xsd#anab_AmortizationOfAdvanceFutureRoyaltiesIssuanceCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_AmortizationOfAdvanceFutureRoyaltiesIssuanceCosts_0e732e1b-e2a6-49c3-8083-c3fd8ff5019d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_4ec2927a-1d90-4e5f-bb16-0907a2b4e359" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltyAndMilestonePayments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_AdvanceFutureRoyaltyAndMilestonePayments_4ec2927a-1d90-4e5f-bb16-0907a2b4e359" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_NoncashInterestExpenseRecognized_c050acdb-9c2b-4a4d-a101-9c637605d2bf" xlink:href="anab-20220630.xsd#anab_NoncashInterestExpenseRecognized"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_NoncashInterestExpenseRecognized_c050acdb-9c2b-4a4d-a101-9c637605d2bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AdvanceFutureRoyaltiesLiabilities_7b7d0845-6f63-4094-9f82-1e52729466ff" xlink:href="anab-20220630.xsd#anab_AdvanceFutureRoyaltiesLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_anab_LiabilitiesRelatedToSaleOfFutureRoyaltiesRollForward_1bf67f90-d103-446e-9a9f-67653ef1c607" xlink:to="loc_anab_AdvanceFutureRoyaltiesLiabilities_7b7d0845-6f63-4094-9f82-1e52729466ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestments" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestments"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_241ee0ba-db2f-4722-84f9-00d84e90ab3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_5c5d3b9a-51e5-4066-b650-1ebf6342ecda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_241ee0ba-db2f-4722-84f9-00d84e90ab3e" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_5c5d3b9a-51e5-4066-b650-1ebf6342ecda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsTables" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_908673de-06f2-4fa8-9a95-c17e855c4523" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_ec072c41-d4d5-4e33-8923-ca9769c7708a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_908673de-06f2-4fa8-9a95-c17e855c4523" xlink:to="loc_us-gaap_ScheduleOfFairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisTableTextBlock_ec072c41-d4d5-4e33-8923-ca9769c7708a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_895bf80a-dfeb-4893-914d-a1a93a56b273" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_908673de-06f2-4fa8-9a95-c17e855c4523" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesReconciliationTableTextBlock_895bf80a-dfeb-4893-914d-a1a93a56b273" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_fd98ffce-1fdb-4a08-84c3-0a4f05fd3b6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_908673de-06f2-4fa8-9a95-c17e855c4523" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_fd98ffce-1fdb-4a08-84c3-0a4f05fd3b6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAssetsandLiabilitiesMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_d39da8ca-8ab6-4287-a830-3bfd30dfddf0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_d39da8ca-8ab6-4287-a830-3bfd30dfddf0" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d98dc96b-1dc1-4dc7-b31b-65484839e84e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d98dc96b-1dc1-4dc7-b31b-65484839e84e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_f570c7bc-fd73-423d-9d5d-202e6c384d59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_d98dc96b-1dc1-4dc7-b31b-65484839e84e" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_f570c7bc-fd73-423d-9d5d-202e6c384d59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_07b934a5-8894-453e-b0c2-048d96e8d9ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_f570c7bc-fd73-423d-9d5d-202e6c384d59" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_07b934a5-8894-453e-b0c2-048d96e8d9ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_eea929d4-9935-418d-a67a-0e7185a556c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_eea929d4-9935-418d-a67a-0e7185a556c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d14be0f6-2a8d-4478-942a-aff8618a708b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_eea929d4-9935-418d-a67a-0e7185a556c4" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d14be0f6-2a8d-4478-942a-aff8618a708b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_5980f5df-50cb-489f-8081-416371347930" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d14be0f6-2a8d-4478-942a-aff8618a708b" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_5980f5df-50cb-489f-8081-416371347930" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_9ddb33c2-2c59-427d-a28e-64287e638d6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d14be0f6-2a8d-4478-942a-aff8618a708b" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_9ddb33c2-2c59-427d-a28e-64287e638d6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_3483ff73-90da-4202-b420-e7b8edc3ec2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d14be0f6-2a8d-4478-942a-aff8618a708b" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_3483ff73-90da-4202-b420-e7b8edc3ec2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_b8aae651-7709-4047-9a5c-854767ff7f2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_b8aae651-7709-4047-9a5c-854767ff7f2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e9352cd1-493b-453f-bdf9-f2667d098d93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_b8aae651-7709-4047-9a5c-854767ff7f2e" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e9352cd1-493b-453f-bdf9-f2667d098d93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_52742c76-6393-4821-8722-efd9fcfd0cab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e9352cd1-493b-453f-bdf9-f2667d098d93" xlink:to="loc_us-gaap_MoneyMarketFundsMember_52742c76-6393-4821-8722-efd9fcfd0cab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MutualFundMember_6b7ea333-53a4-4db3-a5e2-d810787003f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MutualFundMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e9352cd1-493b-453f-bdf9-f2667d098d93" xlink:to="loc_us-gaap_MutualFundMember_6b7ea333-53a4-4db3-a5e2-d810787003f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_d8df2afb-e8d9-450d-b869-8ca6663d9c76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:to="loc_us-gaap_FinancialInstrumentAxis_d8df2afb-e8d9-450d-b869-8ca6663d9c76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_d8df2afb-e8d9-450d-b869-8ca6663d9c76" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_53ce9618-6160-45d0-83ae-add6e7d72026" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_53ce9618-6160-45d0-83ae-add6e7d72026" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_d8ce7ba0-cae0-44cb-8ce9-fdc4cf0984e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:to="loc_us-gaap_CertificatesOfDepositMember_d8ce7ba0-cae0-44cb-8ce9-fdc4cf0984e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_e24a751a-3f44-472f-872d-a2134808f1e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_e24a751a-3f44-472f-872d-a2134808f1e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommercialAndCorporateObligationsMember_84c7c3b0-9475-4b08-84c5-e764dd21af5a" xlink:href="anab-20220630.xsd#anab_CommercialAndCorporateObligationsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_ad8524dc-7ccd-418e-b739-87d09bb4b800" xlink:to="loc_anab_CommercialAndCorporateObligationsMember_84c7c3b0-9475-4b08-84c5-e764dd21af5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_b0ed6ad1-a705-4c7d-8b4c-f2758dbcabc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_744ac757-fb91-4a7f-b21d-6623a834f286" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_b0ed6ad1-a705-4c7d-8b4c-f2758dbcabc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure_353d8105-63e1-491d-a608-322d52861c86" xlink:href="anab-20220630.xsd#anab_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_b0ed6ad1-a705-4c7d-8b4c-f2758dbcabc0" xlink:to="loc_anab_CashAndCashEquivalentsAndRestrictedCashFairValueDisclosure_353d8105-63e1-491d-a608-322d52861c86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f91bdcf1-62e1-4fc9-959a-18420e4f9e35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_b0ed6ad1-a705-4c7d-8b4c-f2758dbcabc0" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f91bdcf1-62e1-4fc9-959a-18420e4f9e35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsAvailableforsaleInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_a8cd9c59-18f7-4667-a815-f819c9670332" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_2fbea163-d94a-4e74-96d7-9c88f4b233ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_a8cd9c59-18f7-4667-a815-f819c9670332" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_2fbea163-d94a-4e74-96d7-9c88f4b233ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_c1c15398-29c6-43e8-98f1-86a78f2aaacf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_2fbea163-d94a-4e74-96d7-9c88f4b233ab" xlink:to="loc_us-gaap_FinancialInstrumentAxis_c1c15398-29c6-43e8-98f1-86a78f2aaacf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_c1c15398-29c6-43e8-98f1-86a78f2aaacf" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_e2f2e645-ee0e-4b72-b7d8-022fb7a24067" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_e2f2e645-ee0e-4b72-b7d8-022fb7a24067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_e1970d55-e8cd-441b-9c29-85ec183dbe46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:to="loc_us-gaap_CertificatesOfDepositMember_e1970d55-e8cd-441b-9c29-85ec183dbe46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommercialAndCorporateObligationsMember_66f02a5b-bcd4-42c1-873e-2e92c0f2ca82" xlink:href="anab-20220630.xsd#anab_CommercialAndCorporateObligationsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:to="loc_anab_CommercialAndCorporateObligationsMember_66f02a5b-bcd4-42c1-873e-2e92c0f2ca82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_186e51b7-54a7-46f5-a762-bc268c8105ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_72339702-cba8-4b39-acc2-d7977c6c174b" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_186e51b7-54a7-46f5-a762-bc268c8105ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_953c8ec6-ed6a-438e-ab13-06eda6ce0fc5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_2fbea163-d94a-4e74-96d7-9c88f4b233ab" xlink:to="loc_srt_RangeAxis_953c8ec6-ed6a-438e-ab13-06eda6ce0fc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2b800414-24a6-4465-810d-f2cf5fe145d0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_953c8ec6-ed6a-438e-ab13-06eda6ce0fc5" xlink:to="loc_srt_RangeMember_2b800414-24a6-4465-810d-f2cf5fe145d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_46dbeeed-fdd8-4745-b183-58a3a8c5c35b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_2b800414-24a6-4465-810d-f2cf5fe145d0" xlink:to="loc_srt_MinimumMember_46dbeeed-fdd8-4745-b183-58a3a8c5c35b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_e0036fb4-11b8-4b54-96f3-8edaa20ae4f0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_2b800414-24a6-4465-810d-f2cf5fe145d0" xlink:to="loc_srt_MaximumMember_e0036fb4-11b8-4b54-96f3-8edaa20ae4f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_2fbea163-d94a-4e74-96d7-9c88f4b233ab" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_37f4e307-2747-4b72-b7ab-bf2a44159a83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_37f4e307-2747-4b72-b7ab-bf2a44159a83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_d30d8368-b97d-4099-94e2-52456a5ec415" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_d30d8368-b97d-4099-94e2-52456a5ec415" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3ab8bc65-e2b8-4e05-b191-de0227b3a285" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3ab8bc65-e2b8-4e05-b191-de0227b3a285" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24aac35d-f6a7-485d-af7d-c73859e9d342" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24aac35d-f6a7-485d-af7d-c73859e9d342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_10e334bd-2350-432b-be5c-c6e5dc1f1321" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_10e334bd-2350-432b-be5c-c6e5dc1f1321" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_7568abb1-2a78-4f53-901d-106cf76827dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_7568abb1-2a78-4f53-901d-106cf76827dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AvailableforsaleDebtSecuritiesRemainingMaturity_78a867a1-7b50-413c-889a-bbbb58ec69cc" xlink:href="anab-20220630.xsd#anab_AvailableforsaleDebtSecuritiesRemainingMaturity"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_34537a74-66c1-42eb-a415-bb021d8da240" xlink:to="loc_anab_AvailableforsaleDebtSecuritiesRemainingMaturity_78a867a1-7b50-413c-889a-bbbb58ec69cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsScheduleofUnrealizedLossandFairValuesinaLossPositionDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_8c56de56-83bf-401f-819c-1f5e9b9a0a7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd8bac49-2efe-4fed-876d-117d8614663b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_8c56de56-83bf-401f-819c-1f5e9b9a0a7c" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd8bac49-2efe-4fed-876d-117d8614663b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_62f31533-d63e-41b7-a06c-44399e4af7cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd8bac49-2efe-4fed-876d-117d8614663b" xlink:to="loc_us-gaap_FinancialInstrumentAxis_62f31533-d63e-41b7-a06c-44399e4af7cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_62f31533-d63e-41b7-a06c-44399e4af7cc" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_298ed3cc-ba70-4277-95ca-0faf90c8b277" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_298ed3cc-ba70-4277-95ca-0faf90c8b277" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommercialAndCorporateObligationsMember_4dbbd982-6412-4d59-8a53-45c0c81b428d" xlink:href="anab-20220630.xsd#anab_CommercialAndCorporateObligationsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:to="loc_anab_CommercialAndCorporateObligationsMember_4dbbd982-6412-4d59-8a53-45c0c81b428d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_af1c79b2-d405-4bb1-a427-14153e4ca00b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:to="loc_us-gaap_CertificatesOfDepositMember_af1c79b2-d405-4bb1-a427-14153e4ca00b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_167cfdcc-999c-45f2-9727-1097304012f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_40545c36-8c0d-471b-8342-7eb4babff442" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_167cfdcc-999c-45f2-9727-1097304012f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_dd8bac49-2efe-4fed-876d-117d8614663b" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_3660bfdf-dda6-4cd7-ad45-ca6d264895e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_3660bfdf-dda6-4cd7-ad45-ca6d264895e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_583ab5e7-f7b0-4e8d-bf2a-2895ade7c4cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_583ab5e7-f7b0-4e8d-bf2a-2895ade7c4cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_de951a30-b0a8-46de-af68-ab8ac2af2e0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_de951a30-b0a8-46de-af68-ab8ac2af2e0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_65545776-94ee-4af6-990b-e0f42a8697d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_65545776-94ee-4af6-990b-e0f42a8697d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_177fa283-5e69-46f1-a0ce-d11a5f0032e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_177fa283-5e69-46f1-a0ce-d11a5f0032e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2385a0f2-2970-4433-8f87-c3cea6a8d937" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_a144655b-fdd4-4692-ae2b-3b0312d32b57" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2385a0f2-2970-4433-8f87-c3cea6a8d937" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsNarrativesDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#FairValueMeasurementsandAvailableforSaleInvestmentsNarrativesDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/FairValueMeasurementsandAvailableforSaleInvestmentsNarrativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1b8b238e-9d95-42e8-84ae-90a7a2390f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss_3164be98-bd3d-4432-9ba3-ff05bae98d39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1b8b238e-9d95-42e8-84ae-90a7a2390f8f" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss_3164be98-bd3d-4432-9ba3-ff05bae98d39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_981c2e28-bd49-4299-bc40-405e3a07f62b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1b8b238e-9d95-42e8-84ae-90a7a2390f8f" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAllowanceForCreditLoss_981c2e28-bd49-4299-bc40-405e3a07f62b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/StockholdersEquity" xlink:type="simple" xlink:href="anab-20220630.xsd#StockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_54e31f60-21ce-40a7-ba8f-12548196cbe6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6566871b-65c9-4bea-94d5-ef0c334dfa01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_54e31f60-21ce-40a7-ba8f-12548196cbe6" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6566871b-65c9-4bea-94d5-ef0c334dfa01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="anab-20220630.xsd#StockholdersEquityTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/StockholdersEquityTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_c21a9a5a-f5dc-4bed-b5fe-1d7a6428e5e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock_dbf24bf4-2ec4-4fde-b916-6d573c86239d" xlink:href="anab-20220630.xsd#anab_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_c21a9a5a-f5dc-4bed-b5fe-1d7a6428e5e1" xlink:to="loc_anab_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock_dbf24bf4-2ec4-4fde-b916-6d573c86239d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#StockholdersEquityNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_ec8c06d8-f877-4581-bc71-579d6aa6550e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_b29d45b0-e814-45f2-a338-3247c104e9dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ec8c06d8-f877-4581-bc71-579d6aa6550e" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_b29d45b0-e814-45f2-a338-3247c104e9dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_fc1ae863-3d93-45b0-b0cc-4e19921e16a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ec8c06d8-f877-4581-bc71-579d6aa6550e" xlink:to="loc_us-gaap_CommonStockSharesIssued_fc1ae863-3d93-45b0-b0cc-4e19921e16a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_1ffdda51-998f-4ae4-aa15-53099196ae4f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ec8c06d8-f877-4581-bc71-579d6aa6550e" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_1ffdda51-998f-4ae4-aa15-53099196ae4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/StockholdersEquitySummaryofCommonStockReservedforFutureIssuanceDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#StockholdersEquitySummaryofCommonStockReservedforFutureIssuanceDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/StockholdersEquitySummaryofCommonStockReservedforFutureIssuanceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_41c4598a-0253-4435-9756-6b58c37598b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_52a1ad03-4975-49c9-a420-8ec60d27b2a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_41c4598a-0253-4435-9756-6b58c37598b8" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_52a1ad03-4975-49c9-a420-8ec60d27b2a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_df7cb2c3-cc36-435e-818b-ae6fdb8ed6f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_52a1ad03-4975-49c9-a420-8ec60d27b2a7" xlink:to="loc_us-gaap_PlanNameAxis_df7cb2c3-cc36-435e-818b-ae6fdb8ed6f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_1a63f522-1dcc-45d9-95ca-722cfc65ec3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_df7cb2c3-cc36-435e-818b-ae6fdb8ed6f5" xlink:to="loc_us-gaap_PlanNameDomain_1a63f522-1dcc-45d9-95ca-722cfc65ec3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_EquityIncentivePlan2017Member_019cb069-40e3-46dd-97f2-6c71c9a29e14" xlink:href="anab-20220630.xsd#anab_EquityIncentivePlan2017Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_1a63f522-1dcc-45d9-95ca-722cfc65ec3f" xlink:to="loc_anab_EquityIncentivePlan2017Member_019cb069-40e3-46dd-97f2-6c71c9a29e14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_EmployeeStockPurchasePlan2017Member_202cad1c-87e4-4673-a170-9980eac2c811" xlink:href="anab-20220630.xsd#anab_EmployeeStockPurchasePlan2017Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_1a63f522-1dcc-45d9-95ca-722cfc65ec3f" xlink:to="loc_anab_EmployeeStockPurchasePlan2017Member_202cad1c-87e4-4673-a170-9980eac2c811" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_bb851c72-ab2f-40a1-bf0c-ea0ec254859a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_52a1ad03-4975-49c9-a420-8ec60d27b2a7" xlink:to="loc_us-gaap_ClassOfStockLineItems_bb851c72-ab2f-40a1-bf0c-ea0ec254859a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockNumberOfSharesParValueAndOtherDisclosuresAbstract_db40b20b-9108-42ca-876b-8fde488e769e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockNumberOfSharesParValueAndOtherDisclosuresAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_bb851c72-ab2f-40a1-bf0c-ea0ec254859a" xlink:to="loc_us-gaap_CommonStockNumberOfSharesParValueAndOtherDisclosuresAbstract_db40b20b-9108-42ca-876b-8fde488e769e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_c76a5396-67d7-441f-98a5-d62bd315244f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommonStockNumberOfSharesParValueAndOtherDisclosuresAbstract_db40b20b-9108-42ca-876b-8fde488e769e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_c76a5396-67d7-441f-98a5-d62bd315244f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_03d97785-7ca7-439d-b25e-887d2eccb2b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommonStockNumberOfSharesParValueAndOtherDisclosuresAbstract_db40b20b-9108-42ca-876b-8fde488e769e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_03d97785-7ca7-439d-b25e-887d2eccb2b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_1cdb50da-861a-4aea-a7ce-a17674970cb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_bb851c72-ab2f-40a1-bf0c-ea0ec254859a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_1cdb50da-861a-4aea-a7ce-a17674970cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_478aff94-7ef5-4fb8-9345-378281659686" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_bb851c72-ab2f-40a1-bf0c-ea0ec254859a" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_478aff94-7ef5-4fb8-9345-378281659686" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlans" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlans"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlans" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_91add6a0-d2ee-4ce3-ad1a-6caafa7f9578" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_cde5c5f0-83b0-4cbe-beef-2d29f6ae1515" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_91add6a0-d2ee-4ce3-ad1a-6caafa7f9578" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_cde5c5f0-83b0-4cbe-beef-2d29f6ae1515" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansTables" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_2db8da15-7282-4259-a1e4-b441917e84ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_676ef328-0354-46cf-80ad-690858e9d04a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_2db8da15-7282-4259-a1e4-b441917e84ec" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_676ef328-0354-46cf-80ad-690858e9d04a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_5dd5c386-74d1-4e9f-8de6-940e01374520" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_2db8da15-7282-4259-a1e4-b441917e84ec" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_5dd5c386-74d1-4e9f-8de6-940e01374520" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_bb2b37b4-e048-4c4c-bd2b-44289b95dd2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_2db8da15-7282-4259-a1e4-b441917e84ec" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_bb2b37b4-e048-4c4c-bd2b-44289b95dd2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock_e98a6b8a-bf33-49e8-8e46-f8250b02c07e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_2db8da15-7282-4259-a1e4-b441917e84ec" xlink:to="loc_us-gaap_ScheduleOfCompensationCostForShareBasedPaymentArrangementsAllocationOfShareBasedCompensationCostsByPlanTableTextBlock_e98a6b8a-bf33-49e8-8e46-f8250b02c07e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansNarrativeDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_44e7c0d3-5835-4112-a2cf-3457baf51c10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_44e7c0d3-5835-4112-a2cf-3457baf51c10" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_691bb5ec-84f2-43e9-9537-377bb242aec0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:to="loc_us-gaap_PlanNameAxis_691bb5ec-84f2-43e9-9537-377bb242aec0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_e0aefcfc-13eb-46b5-9f41-aa36e566bba6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_691bb5ec-84f2-43e9-9537-377bb242aec0" xlink:to="loc_us-gaap_PlanNameDomain_e0aefcfc-13eb-46b5-9f41-aa36e566bba6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_EquityIncentivePlan2017Member_3fd5447e-dee9-4aa4-a149-3cc984dafb8f" xlink:href="anab-20220630.xsd#anab_EquityIncentivePlan2017Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_e0aefcfc-13eb-46b5-9f41-aa36e566bba6" xlink:to="loc_anab_EquityIncentivePlan2017Member_3fd5447e-dee9-4aa4-a149-3cc984dafb8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_EmployeeStockPurchasePlan2017Member_38963582-52d0-417d-aa43-0611881aa400" xlink:href="anab-20220630.xsd#anab_EmployeeStockPurchasePlan2017Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_e0aefcfc-13eb-46b5-9f41-aa36e566bba6" xlink:to="loc_anab_EmployeeStockPurchasePlan2017Member_38963582-52d0-417d-aa43-0611881aa400" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_0fcfe7a1-178b-4e62-a3e5-0e82a83e363f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:to="loc_us-gaap_AwardTypeAxis_0fcfe7a1-178b-4e62-a3e5-0e82a83e363f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_edeb17d2-dea8-4d02-9655-342b887106c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_0fcfe7a1-178b-4e62-a3e5-0e82a83e363f" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_edeb17d2-dea8-4d02-9655-342b887106c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_65d693d6-c12a-4605-885a-d7caaec931cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_edeb17d2-dea8-4d02-9655-342b887106c7" xlink:to="loc_us-gaap_EmployeeStockMember_65d693d6-c12a-4605-885a-d7caaec931cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_40b2fa46-4732-44c9-a37f-303074ef359a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_edeb17d2-dea8-4d02-9655-342b887106c7" xlink:to="loc_us-gaap_EmployeeStockOptionMember_40b2fa46-4732-44c9-a37f-303074ef359a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_59ebf650-48c0-4639-a0d6-127c9f80d854" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_edeb17d2-dea8-4d02-9655-342b887106c7" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_59ebf650-48c0-4639-a0d6-127c9f80d854" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_679265b0-127c-4b8c-a726-b9e54ed04efd" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:to="loc_srt_TitleOfIndividualAxis_679265b0-127c-4b8c-a726-b9e54ed04efd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aba690c7-ad08-4a18-87a7-12a746fe4a2b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_679265b0-127c-4b8c-a726-b9e54ed04efd" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aba690c7-ad08-4a18-87a7-12a746fe4a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_DirectorMember_6346fa8d-436c-47a5-8b00-fdc070e66799" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_DirectorMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aba690c7-ad08-4a18-87a7-12a746fe4a2b" xlink:to="loc_srt_DirectorMember_6346fa8d-436c-47a5-8b00-fdc070e66799" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ChiefExecutiveOfficerMember_2e9f6664-c627-4dcc-965a-6f3caec0283a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ChiefExecutiveOfficerMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aba690c7-ad08-4a18-87a7-12a746fe4a2b" xlink:to="loc_srt_ChiefExecutiveOfficerMember_2e9f6664-c627-4dcc-965a-6f3caec0283a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_21650c03-1445-42c8-9f8f-51c93fba5ca9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:to="loc_srt_CounterpartyNameAxis_21650c03-1445-42c8-9f8f-51c93fba5ca9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7c4e66c0-d0bd-4c05-a7a6-4cd551f4068a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_21650c03-1445-42c8-9f8f-51c93fba5ca9" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7c4e66c0-d0bd-4c05-a7a6-4cd551f4068a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_FormerChiefExecutiveOfficerMember_50382903-b4fa-4e68-87dd-12247a3795c3" xlink:href="anab-20220630.xsd#anab_FormerChiefExecutiveOfficerMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7c4e66c0-d0bd-4c05-a7a6-4cd551f4068a" xlink:to="loc_anab_FormerChiefExecutiveOfficerMember_50382903-b4fa-4e68-87dd-12247a3795c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_InterimPresidentAndChiefExecutiveOfficerMember_29f8ee32-9fdc-4875-a856-b38d36dee05e" xlink:href="anab-20220630.xsd#anab_InterimPresidentAndChiefExecutiveOfficerMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_7c4e66c0-d0bd-4c05-a7a6-4cd551f4068a" xlink:to="loc_anab_InterimPresidentAndChiefExecutiveOfficerMember_29f8ee32-9fdc-4875-a856-b38d36dee05e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5da68668-c89b-4921-8605-68fd4e01fd08" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommonStockCapitalSharesReservedForFutureIssuanceAnnualIncreasePercentOfAggregateSharesOutstanding_26853a20-f631-4109-bc10-a3a4b581fa7a" xlink:href="anab-20220630.xsd#anab_CommonStockCapitalSharesReservedForFutureIssuanceAnnualIncreasePercentOfAggregateSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_anab_CommonStockCapitalSharesReservedForFutureIssuanceAnnualIncreasePercentOfAggregateSharesOutstanding_26853a20-f631-4109-bc10-a3a4b581fa7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_CommonStockCapitalSharesReservedForFutureIssuanceIncrease_32d69334-7643-431b-8443-1bdbfe9a6d33" xlink:href="anab-20220630.xsd#anab_CommonStockCapitalSharesReservedForFutureIssuanceIncrease"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_anab_CommonStockCapitalSharesReservedForFutureIssuanceIncrease_32d69334-7643-431b-8443-1bdbfe9a6d33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_14a08d03-556b-4c39-b599-40e0a721ffe4" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardOfferingPeriod_14a08d03-556b-4c39-b599-40e0a721ffe4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsed_d102ae2d-41e7-47a3-9ad9-c21091b3b8d2" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsed"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsed_d102ae2d-41e7-47a3-9ad9-c21091b3b8d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_37e65fdd-fb2a-40e9-9bab-a256db3b89e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_37e65fdd-fb2a-40e9-9bab-a256db3b89e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_cea0253f-1820-4768-ad48-4303b72503fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_cea0253f-1820-4768-ad48-4303b72503fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardCommonShareEquivalent_3ac4b2ac-4479-495a-ac3d-f6fe9caba319" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardCommonShareEquivalent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardCommonShareEquivalent_3ac4b2ac-4479-495a-ac3d-f6fe9caba319" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedCompensationCost_e7200f24-b119-4c2c-bf83-dd777d9e823b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedCompensationCost"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedCompensationCost_e7200f24-b119-4c2c-bf83-dd777d9e823b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b700bc95-8cc2-4e44-a583-648c10a68f95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b700bc95-8cc2-4e44-a583-648c10a68f95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_aabe1b01-371e-4c5e-b9db-bdc4d5750ad1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_ShareBasedCompensation_aabe1b01-371e-4c5e-b9db-bdc4d5750ad1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_26db3475-23ba-4ab0-8600-4d454af987a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_26db3475-23ba-4ab0-8600-4d454af987a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_01a4c001-7183-4152-a820-e5f71e1f9eac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_01a4c001-7183-4152-a820-e5f71e1f9eac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3bd8d4b1-8c6b-47ce-a1b2-bdad73c92ac9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fffd2967-2eac-493a-9ee3-4afeb6e0b37b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3bd8d4b1-8c6b-47ce-a1b2-bdad73c92ac9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansOptionActivityDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansOptionActivityDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansOptionActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_15eb2aa3-58b5-4ab6-aa45-000b243e6c33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_15eb2aa3-58b5-4ab6-aa45-000b243e6c33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_b1fb8c45-a542-423a-bae1-d03a3dfee16e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_b1fb8c45-a542-423a-bae1-d03a3dfee16e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_b29eb8ce-51fc-44e4-9657-814fca88fc5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_b29eb8ce-51fc-44e4-9657-814fca88fc5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_fc6cee74-b4c8-4d25-a5e1-80128fb60965" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_fc6cee74-b4c8-4d25-a5e1-80128fb60965" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_23b1ed53-7ff4-4626-ab8b-a7ed018a80b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_a17b2bbc-e0de-4cbf-bb82-74b204e11ed3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_23b1ed53-7ff4-4626-ab8b-a7ed018a80b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_f72e25a2-56f0-48cb-a21c-587fe52571cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_f72e25a2-56f0-48cb-a21c-587fe52571cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_2f239a3e-0c4e-4434-92cf-52e77bb62945" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_2f239a3e-0c4e-4434-92cf-52e77bb62945" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_4362743e-55de-4eda-8318-97c1f1ee368c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_4362743e-55de-4eda-8318-97c1f1ee368c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_d6d96e5a-a2a1-4fac-8774-478663f4623e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_d6d96e5a-a2a1-4fac-8774-478663f4623e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_6966c9dd-4f3e-4646-b970-3542363fed15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_6966c9dd-4f3e-4646-b970-3542363fed15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_80af5ad7-ae5b-4423-b749-8e672b51ef1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_924d2a25-4b48-497a-919f-199e4f11b489" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_80af5ad7-ae5b-4423-b749-8e672b51ef1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_ee1f6e49-341e-4690-b66b-4cb8f59458c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_ee1f6e49-341e-4690-b66b-4cb8f59458c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_fa1dadbe-366b-4e38-b987-76576679a3bb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_4d3b1277-51f2-4d8f-af05-01b524f06bed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_4d3b1277-51f2-4d8f-af05-01b524f06bed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_0398c71b-484c-49ea-b6d8-d74277f8e61d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_0398c71b-484c-49ea-b6d8-d74277f8e61d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_08b4df16-e3e3-42c9-ae89-bf742c5893e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_08b4df16-e3e3-42c9-ae89-bf742c5893e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_8404333b-c8c9-4abc-838a-990e4cf31cc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_e07d674a-e6d0-41fa-831d-bb7a96b802fc" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_8404333b-c8c9-4abc-838a-990e4cf31cc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansTimebasedRestrictedStockUnitsDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansTimebasedRestrictedStockUnitsDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansTimebasedRestrictedStockUnitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b4794e42-bdb1-407f-9205-588666d37f86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e4068e7b-7c54-4ce8-a1b8-c9e5c8005b10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b4794e42-bdb1-407f-9205-588666d37f86" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e4068e7b-7c54-4ce8-a1b8-c9e5c8005b10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_aa388cbd-e3c4-49da-80c1-08ea02401a5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e4068e7b-7c54-4ce8-a1b8-c9e5c8005b10" xlink:to="loc_us-gaap_AwardTypeAxis_aa388cbd-e3c4-49da-80c1-08ea02401a5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01d83ec2-556e-46bf-b702-3f76d465cff4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_aa388cbd-e3c4-49da-80c1-08ea02401a5d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01d83ec2-556e-46bf-b702-3f76d465cff4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_263c9f5f-103a-47a0-a607-393494be0044" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_01d83ec2-556e-46bf-b702-3f76d465cff4" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_263c9f5f-103a-47a0-a607-393494be0044" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e4068e7b-7c54-4ce8-a1b8-c9e5c8005b10" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_fe8ec1a9-efc4-485e-9bea-22a81f6016f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_fe8ec1a9-efc4-485e-9bea-22a81f6016f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5c53857d-3f66-480c-8417-010b1b66d373" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5c53857d-3f66-480c-8417-010b1b66d373" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_371b7c3a-e3e5-425b-933a-9f6852c42038" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_371b7c3a-e3e5-425b-933a-9f6852c42038" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_0671af62-b0c3-474b-b5cb-34e1d585fe93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_0671af62-b0c3-474b-b5cb-34e1d585fe93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d65e42a1-3f41-48a3-9e8f-38708eeb3100" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_38249972-fb58-4c40-83c9-f235daec856e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d65e42a1-3f41-48a3-9e8f-38708eeb3100" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingNumber_01eb9f5c-42f5-48a6-b068-0aafeedd5864" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingNumber_01eb9f5c-42f5-48a6-b068-0aafeedd5864" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_b8ad2dd5-4ed9-4731-89f5-364f960733d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_b8ad2dd5-4ed9-4731-89f5-364f960733d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b43f1d40-6e14-4b2d-92c9-a075e3c46c91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_b43f1d40-6e14-4b2d-92c9-a075e3c46c91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_3e6c09fc-e0c8-47b5-9f61-4a8e95e2e321" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_3e6c09fc-e0c8-47b5-9f61-4a8e95e2e321" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_efb2bd6d-0272-4e98-a5b0-1d8d278f9b75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_efb2bd6d-0272-4e98-a5b0-1d8d278f9b75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_d95fd1d1-965b-4fc8-8423-c5508f4d0d34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_2fa53a27-5ab9-4988-a274-d83fabf92fff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_d95fd1d1-965b-4fc8-8423-c5508f4d0d34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue_d428fb5f-30eb-4922-83de-a4d55917f4c1" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageGrantDateFairValue_d428fb5f-30eb-4922-83de-a4d55917f4c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_41c48e67-25e1-416e-bdfe-1d95b39caa42" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_95eabf2c-ce59-4360-bf4c-c51e156f1189" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTerms_95eabf2c-ce59-4360-bf4c-c51e156f1189" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerms_205c8fd3-9dd9-4ea2-92c7-84e267776ffc" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerms"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerms_205c8fd3-9dd9-4ea2-92c7-84e267776ffc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueNonvested_20393b5e-f528-43a1-8541-4db9b2ad1b56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueNonvested"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueNonvested_20393b5e-f528-43a1-8541-4db9b2ad1b56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_8b9d0a63-87bc-4ac5-8bd5-8ebc7afcdab4" xlink:href="anab-20220630.xsd#anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueAbstract_7d4f6168-02ab-406a-bba4-2b036f21e5c5" xlink:to="loc_anab_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_8b9d0a63-87bc-4ac5-8bd5-8ebc7afcdab4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansSummaryofWeightedAverageAssumptionsusedtoEstimateFairValueDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansSummaryofWeightedAverageAssumptionsusedtoEstimateFairValueDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansSummaryofWeightedAverageAssumptionsusedtoEstimateFairValueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_785f0e97-cc36-42df-bb4c-f33736c017f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d70e51f-24bf-46bf-b881-5b062a9fb76a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_785f0e97-cc36-42df-bb4c-f33736c017f0" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d70e51f-24bf-46bf-b881-5b062a9fb76a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_0676d8f6-a5d4-4972-8e50-9a317c40da52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d70e51f-24bf-46bf-b881-5b062a9fb76a" xlink:to="loc_us-gaap_AwardTypeAxis_0676d8f6-a5d4-4972-8e50-9a317c40da52" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c8f5c466-ed97-42b7-b452-354335b8051a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_0676d8f6-a5d4-4972-8e50-9a317c40da52" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c8f5c466-ed97-42b7-b452-354335b8051a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_3b1430bf-9294-45d1-865b-ad2172c60158" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c8f5c466-ed97-42b7-b452-354335b8051a" xlink:to="loc_us-gaap_EmployeeStockOptionMember_3b1430bf-9294-45d1-865b-ad2172c60158" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7d70e51f-24bf-46bf-b881-5b062a9fb76a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_73f852d3-f022-44f1-a2df-b8ba7f40063a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_73f852d3-f022-44f1-a2df-b8ba7f40063a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_fd08fef8-2b9b-49de-a904-73d434350924" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_fd08fef8-2b9b-49de-a904-73d434350924" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7f065491-b99b-4782-a651-f771084846f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_7f065491-b99b-4782-a651-f771084846f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_8fad3618-0b0e-46d8-ba16-d1688b80dbba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_8fad3618-0b0e-46d8-ba16-d1688b80dbba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_71ab8f21-e84e-4525-a57e-a58427e29c27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_016dabf0-d485-49ee-94dd-123253ade789" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_71ab8f21-e84e-4525-a57e-a58427e29c27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/EquityIncentivePlansAllocationofSharebasedCompensationExpenseDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#EquityIncentivePlansAllocationofSharebasedCompensationExpenseDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/EquityIncentivePlansAllocationofSharebasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4326814c-94c2-4c70-9a3e-ad64de1e5937" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9858a173-41a3-4965-95f7-784306d63dff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4326814c-94c2-4c70-9a3e-ad64de1e5937" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9858a173-41a3-4965-95f7-784306d63dff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_e19677b2-f82c-4c1f-843b-8af7f1be7934" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9858a173-41a3-4965-95f7-784306d63dff" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_e19677b2-f82c-4c1f-843b-8af7f1be7934" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_d66a7319-e97f-4575-a71a-b31c743a61ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_e19677b2-f82c-4c1f-843b-8af7f1be7934" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_d66a7319-e97f-4575-a71a-b31c743a61ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_2e450beb-19d0-4045-b700-6e41d374c297" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d66a7319-e97f-4575-a71a-b31c743a61ed" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_2e450beb-19d0-4045-b700-6e41d374c297" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_14dce2c0-b16d-4224-91ff-e1666253fe4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_d66a7319-e97f-4575-a71a-b31c743a61ed" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_14dce2c0-b16d-4224-91ff-e1666253fe4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bc2e1782-d718-437c-af9b-c0d4bbafccdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_9858a173-41a3-4965-95f7-784306d63dff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bc2e1782-d718-437c-af9b-c0d4bbafccdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_0eab8162-2d2d-4c21-a045-19122b8b09a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bc2e1782-d718-437c-af9b-c0d4bbafccdf" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_0eab8162-2d2d-4c21-a045-19122b8b09a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_e5792b4e-3871-475f-a81d-23e4ccec02e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_03ea9b43-e607-459b-86de-d0cd7178c224" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_e5792b4e-3871-475f-a81d-23e4ccec02e0" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_03ea9b43-e607-459b-86de-d0cd7178c224" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesTables" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingenciesTables"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5e8f19b4-f5ea-4ff7-8039-509a4d4b1196" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_ac6e819a-7772-438e-bce0-d350efea420d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCostTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5e8f19b4-f5ea-4ff7-8039-509a4d4b1196" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_ac6e819a-7772-438e-bce0-d350efea420d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_c26b6100-a6a8-4c48-97d1-8ad2270949a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5e8f19b4-f5ea-4ff7-8039-509a4d4b1196" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_c26b6100-a6a8-4c48-97d1-8ad2270949a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_db69ed58-4ef0-41d4-b815-765ddfded6ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_9fb84331-c101-442b-8063-2f2959e4d1a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_db69ed58-4ef0-41d4-b815-765ddfded6ad" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_9fb84331-c101-442b-8063-2f2959e4d1a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_7f29966e-26b0-4363-ace4-18ea51bb143b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_9fb84331-c101-442b-8063-2f2959e4d1a9" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_7f29966e-26b0-4363-ace4-18ea51bb143b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_7ecb83dc-05a2-4908-82ef-fcb28e8097a4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_7f29966e-26b0-4363-ace4-18ea51bb143b" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_7ecb83dc-05a2-4908-82ef-fcb28e8097a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_A10770WateridgeCircleSanDiegoCalifornia92121Member_9911a77b-fa5d-4c73-b2d0-e50a7249c3aa" xlink:href="anab-20220630.xsd#anab_A10770WateridgeCircleSanDiegoCalifornia92121Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_7ecb83dc-05a2-4908-82ef-fcb28e8097a4" xlink:to="loc_anab_A10770WateridgeCircleSanDiegoCalifornia92121Member_9911a77b-fa5d-4c73-b2d0-e50a7249c3aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_9fb84331-c101-442b-8063-2f2959e4d1a9" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AreaOfRealEstateProperty_9dd0cc22-1868-4d19-b2e7-7e1a66ab512f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AreaOfRealEstateProperty"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_AreaOfRealEstateProperty_9dd0cc22-1868-4d19-b2e7-7e1a66ab512f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_c651d0d3-a855-4109-ad3a-9411a01cd8af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedTermOfContract1_c651d0d3-a855-4109-ad3a-9411a01cd8af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedRenewalTerm1_cfea806a-50dd-4427-912f-128ab203b2df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedRenewalTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLeaseNotYetCommencedRenewalTerm1_cfea806a-50dd-4427-912f-128ab203b2df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LesseeOperatingLeaseLeaseNotyetCommencedExpirationPeriod_db2de42d-55d3-40f3-b587-c55443a619d7" xlink:href="anab-20220630.xsd#anab_LesseeOperatingLeaseLeaseNotyetCommencedExpirationPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_anab_LesseeOperatingLeaseLeaseNotyetCommencedExpirationPeriod_db2de42d-55d3-40f3-b587-c55443a619d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_RentPerSquareFoot_cc19f69d-3ab6-405a-9edd-7b51bde13538" xlink:href="anab-20220630.xsd#anab_RentPerSquareFoot"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_anab_RentPerSquareFoot_cc19f69d-3ab6-405a-9edd-7b51bde13538" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_AnnualRentIncreasePercent_237d005f-fbbc-41c0-abad-4f829b8b17ef" xlink:href="anab-20220630.xsd#anab_AnnualRentIncreasePercent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_anab_AnnualRentIncreasePercent_237d005f-fbbc-41c0-abad-4f829b8b17ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_43fd3f90-5a82-409c-a2aa-430964482dfd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_43fd3f90-5a82-409c-a2aa-430964482dfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_c1c56611-970d-4a4c-877c-8a6db06aa4ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_OperatingLeaseLiability_c1c56611-970d-4a4c-877c-8a6db06aa4ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecurityDeposit_76245f50-c248-4388-aeab-4b82d969bbfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecurityDeposit"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_SecurityDeposit_76245f50-c248-4388-aeab-4b82d969bbfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_b4c86587-eca4-43d1-878e-95ea8609b02f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_b4c86587-eca4-43d1-878e-95ea8609b02f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_09b7e155-1905-4823-ad89-923970a09856" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_dc9c9e5e-bef5-4acb-bc88-b69a0d6d1aa3" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_09b7e155-1905-4823-ad89-923970a09856" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesCostsIncludedinCashFlowStatementDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingenciesCostsIncludedinCashFlowStatementDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesCostsIncludedinCashFlowStatementDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1ad5e225-6488-44fe-bb4b-c6367162e3c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_b06bc0f5-be17-4e27-888c-782c2d673e19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1ad5e225-6488-44fe-bb4b-c6367162e3c0" xlink:to="loc_us-gaap_OperatingLeaseCost_b06bc0f5-be17-4e27-888c-782c2d673e19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_30698f91-6bb6-4d82-adcf-152cc4c18a2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasePayments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_1ad5e225-6488-44fe-bb4b-c6367162e3c0" xlink:to="loc_us-gaap_OperatingLeasePayments_30698f91-6bb6-4d82-adcf-152cc4c18a2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_104de4e1-8db7-460c-b120-3251738d78ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_104de4e1-8db7-460c-b120-3251738d78ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_dff2d3d3-d31e-4800-9c9f-3431e463104b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_dff2d3d3-d31e-4800-9c9f-3431e463104b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_dabef4f6-d06c-48b2-966c-3f2ed7e59b32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_dabef4f6-d06c-48b2-966c-3f2ed7e59b32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_48fec86b-a610-49ca-a0e3-9b0a0bc857de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_48fec86b-a610-49ca-a0e3-9b0a0bc857de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_fa4d8454-6bbb-431c-a1c7-d279ca78bbef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_fa4d8454-6bbb-431c-a1c7-d279ca78bbef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_anab_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_93fec7d1-5fe2-4461-ae9d-3e321452b6e0" xlink:href="anab-20220630.xsd#anab_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_anab_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_93fec7d1-5fe2-4461-ae9d-3e321452b6e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_851d685c-40e3-4e22-a243-bc2635656b30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_851d685c-40e3-4e22-a243-bc2635656b30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_35cce59e-5c7c-4750-9b66-d69af845c283" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_35cce59e-5c7c-4750-9b66-d69af845c283" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_fec6cc48-3ad9-44a2-8841-5b37fdbb7cd1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_782b0d7b-a73f-4d7a-8610-225fde9e6675" xlink:to="loc_us-gaap_OperatingLeaseLiability_fec6cc48-3ad9-44a2-8841-5b37fdbb7cd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails_1" xlink:type="simple" xlink:href="anab-20220630.xsd#CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails_1"/>
  <link:presentationLink xlink:role="http://www.anaptysbio.com/role/CommitmentsandContingenciesScheduleofFutureMinimumAnnualObligationsDetails_1" xlink:type="extended"/>
</link:linkbase>
