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Disclosure - Description of the Business (Details) link:presentationLink link:calculationLink link:definitionLink 2103102 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2204201 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2407403 - Disclosure - Summary of Significant Accounting Policies - Summary of Potentially Dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2108103 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures link:presentationLink link:calculationLink link:definitionLink 2309302 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures (Tables) link:presentationLink link:calculationLink link:definitionLink 2410404 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2411405 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 2112104 - Disclosure - Collaborative Research and Development Agreements link:presentationLink link:calculationLink link:definitionLink 2313303 - Disclosure - Collaborative Research and Development Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2414406 - Disclosure - Collaborative Research and Development Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2115105 - Disclosure - Notes Payable link:presentationLink link:calculationLink link:definitionLink 2416407 - Disclosure - Notes Payable (Details) link:presentationLink link:calculationLink link:definitionLink 2117106 - Disclosure - Fair Value Measurements and Available for Sale Investments link:presentationLink link:calculationLink link:definitionLink 2318304 - Disclosure - Fair Value Measurements and Available for Sale Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 2419408 - Disclosure - Fair Value Measurements and Available for Sale Investments - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 2420409 - Disclosure - Fair Value Measurements and Available for Sale Investments - Fair Value of Other Financial Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 2421410 - Disclosure - Fair Value Measurements and Available for Sale Investments - Available-for-sale Investments (Details) link:presentationLink link:calculationLink link:definitionLink 2422411 - Disclosure - Fair Value Measurements and Available for Sale Investments - Schedule of Unrealized Loss and Fair Values in a Loss Position (Details) link:presentationLink link:calculationLink link:definitionLink 2423412 - Disclosure - Fair Value Measurements and Available for Sale Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2124107 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 2325305 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2426413 - Disclosure - Stockholders' Equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2427414 - Disclosure - Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 2128108 - Disclosure - Equity Incentive Plans link:presentationLink link:calculationLink link:definitionLink 2329306 - 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Disclosure - Employee Benefit Plan (Details) link:presentationLink link:calculationLink link:definitionLink 2138111 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2339307 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 2440421 - Disclosure - Commitments and Contingencies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2441422 - Disclosure - Commitments and Contingencies - Schedule of ROU Assets and Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2442423 - Disclosure - Commitments and Contingencies - Costs in Cash Flow Statement (Details) link:presentationLink link:calculationLink link:definitionLink 2443424 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations under Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 2443424 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations under Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 2144112 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 2345308 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 2446425 - Disclosure - Income Taxes - Components of income/(loss) before income tax provision (benefit) (Details) link:presentationLink link:calculationLink link:definitionLink 2447426 - Disclosure - Income Taxes - Deferred tax assets and liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 2448427 - Disclosure - Income Taxes - Additional information (Details) link:presentationLink link:calculationLink link:definitionLink 2449428 - Disclosure - Income Taxes - Reconciliation of income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 2450429 - Disclosure - Income Taxes - Unrecognized tax benefits (Details) link:presentationLink link:calculationLink link:definitionLink 2151113 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink 2452430 - Disclosure - Subsequent Event (Details) link:presentationLink link:calculationLink link:definitionLink