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Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2203201 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2304301 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 2405401 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Summary of Significant Accounting Policies - Summary of Potentially Dilutive Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2107103 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures link:presentationLink link:calculationLink link:definitionLink 2308302 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures (Tables) link:presentationLink link:calculationLink link:definitionLink 2409403 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Property and Equipment, net (Details) link:presentationLink link:calculationLink link:definitionLink 2410404 - Disclosure - Balance Sheet Accounts and Supplemental Disclosures - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 2111104 - Disclosure - Collaborative Research and Development Agreements link:presentationLink link:calculationLink link:definitionLink 2312303 - Disclosure - Collaborative Research and Development Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2413405 - Disclosure - Collaborative Research and Development Agreements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2414406 - Disclosure - Collaborative Research and Development Agreements - Schedule of Milestone Achieved (Details) link:presentationLink link:calculationLink link:definitionLink 2415407 - Disclosure - Collaborative Research and Development Agreements - Scheduel of Future Revenue, Not Yet Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 2116105 - Disclosure - Sale of Future Royalties link:presentationLink link:calculationLink link:definitionLink 2317304 - Disclosure - Sale of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 2418408 - Disclosure - Sale of Future Royalties - Narratives (Details) link:presentationLink link:calculationLink link:definitionLink 2419409 - Disclosure - Sale of Future Royalties - Schedule of Royalty Transaction Activity (Details) link:presentationLink link:calculationLink link:definitionLink 2120106 - Disclosure - Fair Value Measurements and Available for Sale Investments link:presentationLink link:calculationLink link:definitionLink 2321305 - Disclosure - Fair Value Measurements and Available for Sale Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 2422410 - Disclosure - Fair Value Measurements and Available for Sale Investments - 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Disclosure - Stockholders' Equity - Summary of Common Stock Reserved for Future Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 2130108 - Disclosure - Equity Incentive Plans link:presentationLink link:calculationLink link:definitionLink 2331307 - Disclosure - Equity Incentive Plans (Tables) link:presentationLink link:calculationLink link:definitionLink 2432416 - Disclosure - Equity Incentive Plans - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2433417 - Disclosure - Equity Incentive Plans - Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 2434418 - Disclosure - Equity Incentive Plans - Time-based Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 2435419 - Disclosure - Equity Incentive Plans - Summary of Weighted Average Assumptions used to Estimate Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 2436420 - Disclosure - Equity Incentive Plans - Allocation of Share-based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 2137109 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2338308 - Disclosure - Commitments and Contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 2439421 - Disclosure - Commitments and Contingencies - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2440422 - Disclosure - Commitments and Contingencies - Costs Included in Cash Flow Statement (Details) link:presentationLink link:calculationLink link:definitionLink 2441423 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 2441423 - Disclosure - Commitments and Contingencies - Schedule of Future Minimum Annual Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 2142110 - Disclosure - Subsequent Event link:presentationLink link:calculationLink link:definitionLink